Results 41 to 50 of about 2,229,811 (302)

Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2

Cell Reports, 2016
Temporal separation of DNA replication initiation into licensing and firing phases ensures the precise duplication of the genome during each cell cycle.
Karl-Uwe Reusswig, Fabian Zimmermann, Lorenzo Galanti, Boris Pfander   +3 more
doaj   +1 more source

Does the Cytoplasmic Tail Matter? Mechanism of Viral Envelope Glycoprotein Targeting by Membrane-Associated-RING-CH (MARCH) Proteins

Proceedings, 2020
The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety of roles in the downregulation of cell-surface proteins involved in adaptive immunity.
Cheng man Lun, Abdul A. Waheed, Eric O. Freed   +2 more
doaj   +1 more source

Drf1-dependent Kinase Interacts with Claspin through a Conserved Protein Motif [PDF]

, 2010
The Dbf4/Drf1-dependent kinase (DDK) is required for the initiation of DNA replication in eukaryotes. Another protein, Claspin, mediates the activation of a cellular checkpoint response to stalled replication forks and is also a regulator of replication.
Aparicio, Arias, Chini, Chini, Clarke, Daniel A. Gold, Gambus, Hodgson, Jeong, Jiang, Kastan, Katou, Kim, Kumagai, Kumagai, Kumagai, Kumagai, Kumagai, Kumagai, Lee, Lee, Lin, Lou, Masai, Masai, Melo, Montagnoli, Moyer, Osborn, Pacek, Petermann, Roberts, Sar, Sheu, Silva, Ström, Szyjka, Takahashi, Takahashi, Takeda, Tenca, Tourrière, Tsuji, Tsuji, Walter, William G. Dunphy, Yanow, Yoo, Zou   +48 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis

Nature Communications
The eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while ATP hydrolysis is essential for consecutive steps in pre ...
Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li, Christian Speck   +11 more
doaj   +1 more source

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

mBio, 2020
HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu   +7 more
doaj   +1 more source

Teaching Replication

Perspectives on Psychological Science, 2012
Replication is held as the gold standard for ensuring the reliability of published scientific literature. But conducting direct replications is expensive, time-consuming, and unrewarded under current publication practices. So who will do them? Our answer is that students in laboratory classes should replicate recent findings as part of their training ...
uploaded via Dissemin, Michael C. Frank, Rebecca Saxe   +2 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion

The EMBO Journal
The CD225/Dispanin superfamily contains membrane proteins that regulate vesicular transport and membrane fusion events required for neurotransmission, glucose transport, and antiviral immunity.
Kazi Rahman, Isaiah Wilt, Abigail A Jolley, Bhabadeb Chowdhury, Siddhartha A K Datta, Alex A Compton   +5 more
doaj   +1 more source

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. [PDF]

, 2016
Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however ...
Bhushan, Anil, Dhawan, Sangeeta, Dirice, Ercument, Kulkarni, Rohit N   +3 more
core   +1 more source