Results 61 to 70 of about 1,569,783 (304)

A new decentralized periodic replication strategy for dynamic data grids [PDF]

, 2014
Data grids provide scalable infrastructure for storage resource and data files management, which support data-intensive applications that need to access to huge amount of data stored at distributed locations around the world.
Charrada, Faouzi Ben, Chettaoui, Hanene
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging

Viruses
During retrovirus assembly, Gag packages unspliced viral RNA as the virion genome. Genome packaging is usually specific with occasional exceptions of cross-packaging RNA from distantly related retroviruses.
Zetao Cheng, Olga A. Nikolaitchik, Alice Duchon, Jonathan M. O. Rawson, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Replication ethics [PDF]

Futures, 2019
Suppose some future technology enables the same consciously experienced human life to be repeated, identically or nearly so, N times, in series or in parallel. Is this roughly N times as valuable as enabling the same life once, because each life has value and values are additive?
openaire   +3 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

replication-package-motif-action-study.zip

, 2023
 Replication package for motif action study. 
M A (13993116)
core   +1 more source

Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation

Nature Communications
Regulated helicase activation by DDK kinase is central for genome stability. However, how DDK phosphorylation primes the MCM2-7 double hexamer (DH) for Sld3-Sld7 binding and Cdc45 loading remained unclear.
Yasunori Noguchi, Almutasem Saleh, Sarah Schneider, Marina E. Ivanova, Zhuo Angel Chen, Lepakshi Ranjha, Ricardo Aramayo, Silvia Tognetti, Sarah V. Faull, Juri Rappsilber, Christian Speck   +10 more
doaj   +1 more source

Development of a Complementation Assay to Monitor Pan-Coronavirus 3C-like Protease Activity

Viruses
Coronaviruses pose a global pandemic threat, making development of a pan-coronavirus inhibitor crucial for preparedness and containment in the event of a new coronavirus outbreak.
Akhil Chameettachal, Alice Duchon, Matthew A. Brown, Jonathan M. O. Rawson, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Distinct Contributions of Different Domains within the HIV-1 Gag Polyprotein to Specific and Nonspecific Interactions with RNA

Viruses, 2020
Viral genomic RNA is packaged into virions with high specificity and selectivity. However, in vitro the Gag specificity towards viral RNA is obscured when measured in buffers containing physiological salt. Interestingly, when the binding is challenged by
Tomas Kroupa, Siddhartha A. K. Datta, Alan Rein   +2 more
doaj   +1 more source

A New Replicator: A theoretical framework for analysing replication [PDF]

BMC Biology, 2010
Replicators are the crucial entities in evolution. The notion of a replicator, however, is far less exact than the weight of its importance. Without identifying and classifying multiplying entities exactly, their dynamics cannot be determined appropriately.
Zachar, István, Szathmáry, Eörs
openaire   +4 more sources