Results 11 to 20 of about 2,229,811 (302)
Cell-cycle regulated transcription associates with DNA replication timing in yeast and human [PDF]
, 2013 Eukaryotic DNA replication follows a specific temporal program, with some genomic regions consistently replicating earlier than others, yet what determines this program is largely unknown.
Fraser, Hunter B.
core +1 more source
Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase [PDF]
, 2015 Chronic infection of the liver by hepatitis C virus (HCV) induces a range of host factors including IFN-stimulated genes such as ISG15. ISG15 functions as an antiviral factor that limits virus replication. Previous studies have suggested that ISG15 could
Bamford, Connor G.G. +3 more
core +5 more sources
eLife, 2015 We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes.
Roxana E Georgescu +7 more
doaj +1 more source
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing [PDF]
, 2001 Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events when earlier events are improperly executed. Here we describe evidence for the participation of Chk1 in an intra-S phase checkpoint in mammalian cells.
Feijoo, Carmen +6 more
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Replication, Replication [PDF]
PS: Political Science & Politics, 1995 Political science is a community enterprise; the community of empirical political scientists needs access to the body of data necessary to replicate existing studies to understand, evaluate, and especially build on this work. Unfortunately, the norms we have in place now do not encourage, or in some cases even permit, this aim.
openaire +2 more sources
Semiconservative Replication in the Quasispecies Model [PDF]
, 2003 This paper extends Eigen's quasispecies equations to account for the semiconservative nature of DNA replication. We solve the equations in the limit of infinite sequence length for the simplest case of a static, sharply peaked fitness landscape.
Deeds, Eric J. +2 more
core +2 more sources
The role of integration and clonal expansion in HIV infection: live long and prosper
Retrovirology, 2018 Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that ...
Elizabeth M. Anderson, Frank Maldarelli
doaj +1 more source
Restriction of Influenza A Virus by SERINC5
mBio, 2022 Serine incorporator 5 (Ser5), a transmembrane protein, has recently been identified as a host antiviral factor against human immunodeficiency virus (HIV)-1 and gammaretroviruses like murine leukemia viruses (MLVs). It is counteracted by HIV-1 Nef and MLV
Kin Kui Lai +5 more
doaj +1 more source
Dna2 Helicase/Nuclease Causes Replicative Fork Stalling and Double-strand Breaks in the Ribosomal DNA of Saccharomyces cerevisiae [PDF]
, 2003 We have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and contributes to the shortened lifespan of dna2 mutants. Now we use the ribosomal DNA locus,
Budd, Martin +3 more
core +2 more sources
Nature, 1985 The replication of DNA is the process by means of which genetic information is passed from one generation to the next in all living organisms. It is widely believed that a similar process must have become important early in the development of life on the Earth, either before or at the same time as the evolution of protein synthesis.
openaire +2 more sources