Results 11 to 20 of about 1,502,813 (305)

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]

, 2010
In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Blow, J. Julian; id_orcid, Thomson, Alexander M., Gillespie, Peter J., Peter J. Gillespie, J. Julian Blow, Blow, J. Julian, Alexander M. Thomson   +6 more
core   +1 more source

Mathematical modelling of whole chromosome replication [PDF]

, 2010
All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S., de Moura, Alessandro Paula Servio, Retkute, Renata, Nieduszynski, Conrad A., Hawkins, Michelle   +4 more
core   +1 more source

Reversal of terminal differentiation and control of DNA replication [PDF]

, 1993
DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina, Leonhardt, Heinrich, Nadal-Ginard, Bernardo, Nadal-Ginard, B., Leonhardt, H.   +4 more
core   +2 more sources

The mechanism of replication stalling and recovery within repetitive DNA

Nature Communications, 2022
DNA replication of repetitive sequences was recreated in a test tube using purified components. DNA alone was sufficient to induce stalling. Both stalling and recovery were dictated by the capacity of DNA to fold into unusual secondary structures.
Corella S. Casas-Delucchi, Manuel Daza-Martin, Sophie L. Williams, Gideon Coster   +3 more
doaj   +1 more source

Replicability and replication in the humanities [PDF]

Research Integrity and Peer Review, 2019
A large number of scientists and several news platforms have, over the last few years, been speaking of a replication crisis in various academic disciplines, especially the biomedical and social sciences. This paper answers the novel question of whether we should also pursue replication in the humanities.
openaire   +4 more sources

replication

, 2022
Individual SPM and VOI files, for the replication sample.
David Coynel (13821943)
core   +1 more source

Pathological replication in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Little is known about what happens when forks meet to complete DNA replication in any organism.
Lloyd, RG, Robert G. Lloyd, Lynda Harris, Harris, L, Christian J. Rudolph, Amy L. Upton, Rudolph, CJ, Upton, AL   +7 more
core   +1 more source

Replication of Routines and Capabilities: From Knowledge Transfer to Replication as a Social Practice [PDF]

, 2010
Replication of routines and capabilities has been largely neglected in recent research. In this paper we present the current state of research on replication and suggest conceptualizing replication as a social practice.
Friesl, M, Larty, J
core   +4 more sources

The role of integration and clonal expansion in HIV infection: live long and prosper

Retrovirology, 2018
Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that ...
Elizabeth M. Anderson, Frank Maldarelli
doaj   +1 more source

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

eLife, 2021
The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
doaj   +1 more source