Results 241 to 250 of about 3,781,819 (347)

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

HIV-1 and Its Strategy for Hiding Viral cDNA from STING-Mediated Innate Immunity. [PDF]

Int J Mol Sci
Mashkovskaia A, Agapkina Y, Oretskaya T, Gottikh M, Anisenko A.   +4 more
europepmc   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Poxvirus H5 mediates the formation of liquid-liquid phase separation condensates which promote virus factory assembly. [PDF]

PLoS Pathog
Zhu J, Zhang Z, Fang Y, Xu J, Jiang Z, Li H, Xie S, Niu K, Jing Z, Song B, Wu W, Peng C.   +11 more
europepmc   +1 more source

Development of Antibacterial Cotton‐Black Viscose and Cotton‐Polyester Blended‐Knit Fabric Using Ag Doped ZnO Nanocomposite

Advanced Materials Interfaces, EarlyView.
This research unveils a novel approach by bridging material science with textile innovation to create intelligent antimicrobial fabrics by engineering silver‐doped zinc oxide nanocomposites onto cotton–viscose and cotton–polyester blended knits. The work transcends conventional textile innovation through a comprehensive evaluation of structural ...
Dipa Saha, Ador Alam Alvi, Monabbir Rafsan Fahim, Tanu Arefin   +3 more
wiley   +1 more source

Chronic Hepatitis B Virus Infection Acquired Under Cytostatic Treatment in Childhood - Clinical, Virological and Immunological Long-Term Follow-Up. [PDF]

J Viral Hepat
Baumgarten T, Lehmann F, Senff T, Slanina H, Schüttler CG, Walker A, Gerlich WH, Repp R, Timm J, Glebe D, Metzler M.   +10 more
europepmc   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Enhanced Trapping with an Optimized Graphene‐Based Bowtie Plasmonic Nanotweezer: Design, Analysis, and Bioanalytical Applications

Advanced Photonics Research, EarlyView.
A graphene‐based bowtie plasmonic nanotweezer is designed and optimized using particle swarm optimization and transfer matrix analysis. The structure achieves strong field confinement, delivering trapping forces up to 6 nN W−1 for 10 nm bioparticles with sixfold lower power requirements than conventional designs.
Saba Ebrahimpanah, Mohammad Hazhir Mozaffari, Ali Farmani   +2 more
wiley   +1 more source

Correlation analysis of the copy number of aqueous humor HSV DNA with anterior chamber reaction, topical steroid responsiveness and prognosis of endothelial herpes simplex keratitis. [PDF]

BMC Ophthalmol
Yang J.
europepmc   +1 more source