Results 91 to 100 of about 657,941 (288)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

An Electrochemical DNA Microbiosensor Based on Succinimide-Modified Acrylic Microspheres

Sensors, 2012
An electrochemical microbiosensor for DNA has been fabricated based on new acrylic microspheres modified with reactive <em>N</em>-acryloxysuccinimide (NAS) functional groups.
Sharina Abu Hanifah, Tan Ling Ling, Alizar Ulianas, Lee Yook Heng   +3 more
doaj   +1 more source

Bismuth oxide nanoparticles/chitosan/modified electrode as biosensor for DNA hybridization. [PDF]

, 2011
An electrochemical DNA biosensor based on nanoparticles bismuth oxide Bi2O3 for DNA immobilization and hybridization detection is presented. The nano Bi2O3/chitosan-modified gold electrode (AuE) was fabricated and oligonucleotides were immobilized onto ...
Ramli, Irmawati, Tan, Wee Tee, Taufik, Safura, Yusof, Nor Azah   +3 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Electrochemical Detection of Sequence-Specific DNA with the Amplification of Gold Nanoparticles

International Journal of Electrochemistry, 2011
A sensitive electrochemical DNA biosensor was prepared based on mercaptoacetic acid (MAA)/gold nanoparticles (AuNPs) modified electrode. Probe DNA (NH2-DNA) was covalently linked to the carboxyl group of MAA in the presence of 1-ethyl-3-(3 ...
Yuzhong Zhang, Zhen Wang, Yuehong Wang, Lei Huang, Wei Jiang, Mingzhu Wang   +5 more
doaj   +1 more source

Electrochemical DNA Hybridization Sensors Based on Conducting Polymers

Sensors, 2015
Conducting polymers (CPs) are a group of polymeric materials that have attracted considerable attention because of their unique electronic, chemical, and biochemical properties.
Md. Mahbubur Rahman, Xiao-Bo Li, Nasrin Siraj Lopa, Sang Jung Ahn, Jae-Joon Lee   +4 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Target-Triggered Polymerization of Branched DNA Enables Enzyme-free and Fast Discrimination of Single-Base Changes

iScience, 2019
Summary: Single-base changes lead to important biological and biomedical implications; however, the discrimination of single-base changes from normal DNA always remains a grand challenge.
Yuhang Dong, Chi Yao, Zhi Wang, Dan Luo, Dayong Yang   +4 more
doaj   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source