Results 71 to 80 of about 410,825 (308)

The Role OF DNA Polymerases in Carcinogenesis

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2016
Background and Objectives: The major role of various types of DNA polymerases is genome replication. However, DNA polymerases are also necessary to establish the accuracy, efficiency of replication, repairing process, and consequently decrease in ...
Zahra Aghelan, Mojtaba Panjehpour
doaj  

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

Cell Reports, 2023
Summary: The PSMC3IP-MND1 heterodimer promotes meiotic D loop formation before DNA strand exchange. In genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, depletion of PSMC3IP or MND1 causes sensitivity to poly (ADP-Ribose ...
Anabel Zelceski, Paola Francica, Lea Lingg, Merve Mutlu, Colin Stok, Martin Liptay, John Alexander, Joseph S. Baxter, Rachel Brough, Aditi Gulati, Syed Haider, Maya Raghunandan, Feifei Song, Sandhya Sridhar, Josep V. Forment, Mark J. O’Connor, Barry R. Davies, Marcel A.T.M. van Vugt, Dragomir B. Krastev, Stephen J. Pettitt, Andrew N.J. Tutt, Sven Rottenberg, Christopher J. Lord   +22 more
doaj   +1 more source

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier. [PDF]

, 2019
Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II ...
Brown, Aidan I, Bustamante, Carlos, Chen, Zhijie, Díaz-Celis, César, Gabizon, Ronen, Kaplan, Craig D, Koslover, Elena F, Lee, Antony, Song, Aixin, Yao, Tingting   +9 more
core   +2 more sources

DNA-directed termination of mammalian RNA polymerase II

Genes & Development
ABSTRACT The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII-associated cleavage product is then degraded by XRN2, dislodging RNAPII from the DNA template.
Davidson, Lee, Rouvière, Jérôme O.; id_orcid 0000-0002-0269-1971, Sousa-Luís, Rui, Nojima, Takayuki, Proudfoot, Nicholas J., Jensen, Torben Heick; id_orcid 0000-0001-5127-1239, West, Steven   +6 more
openaire   +3 more sources

Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases [PDF]

Biochemical Journal, 1997
A natural compound from the Red Sea sponge Ircinia sp., 2-hexaprenylhydroquinone (HPH), has been shown to be a general inhibitor of retroviral reverse transcriptases (from HIV-1, HIV-2 and murine leukaemia virus) as well as of cellular DNA polymerases (Escherichia coli DNA polymerase I, and DNA polymerases α and β).
S, Loya, A, Rudi, Y, Kashman, A, Hizi
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Tyrosines involved in the activity of φ29 single-stranded DNA binding protein.

PLoS ONE, 2019
The genome of Bacillus subtilis phage ϕ29 consists of a linear double-stranded DNA with a terminal protein (TP) covalently linked to each 5' end (TP-DNA).
Iván de la Torre, Victor Quiñones, Margarita Salas, Alicia Del Prado   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. [PDF]

, 2011
In the early 'RNA world' stage of life, RNA stored genetic information and catalyzed chemical reactions. However, the RNA world eventually gave rise to the DNA-RNA-protein world, and this transition included the 'genetic takeover' of information storage ...
Chen, Irene A, Gerland, Ulrich, Leu, Kevin, Obermayer, Benedikt, Rajamani, Sudha   +4 more
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source