Results 1 to 10 of about 299 (89)
Polymerase Mu Is a DNA-Directed DNA/RNA Polymerase [PDF]
Molecular and Cellular Biology, 2003 DNA polymerases are defined as such because they use deoxynucleotides instead of ribonucleotides with high specificity. We show here that polymerase mu (pol μ), implicated in the nonhomologous end-joining pathway for repair of DNA double-strand breaks, incorporates both ribonucleotides and deoxynucleotides in a template-directed manner.
Stephanie A. Nick McElhinny +1 more
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On the Binding of Rifampicin to the DNA‐Directed RNA Polymerase from Escherichia coli [PDF]
European Journal of Biochemistry, 1973 The capacity of RNA polymerase to bind the antibiotic rifampicin is rather sensitive to conditions which lead to conformational changes in the enzyme. Repeated freezing and thawing in 1 M LiCl as well as treatment with guanidinium chloride destroys the binding affinity of the enzyme for the inhibitor. Similarly rifampicin does not associate with any of
Guido R. Hartmann, Ute Lill
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Mode of inhibition of HIV-1 reverse transcriptase by polyacetylenetriol, a novel inhibitor of RNA- and DNA-directed DNA polymerases [PDF]
Biochemical Journal, 2002 Polyacetylenetriol (PAT), a natural marine product from the Mediterranean sea sponge Petrosia sp., was found to be a novel general potent inhibitor of DNA polymerases. It inhibits equally well the RNA- and DNA-dependent DNA polymerase activities of retroviral reverse transcriptases (RTs) (i.e.
Amnon Hizi +3 more
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DNA-directed termination of mammalian RNA polymerase II
Genes & DevelopmentABSTRACTThe best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII-associated cleavage product is then degraded by XRN2, dislodging RNAPII from the DNA template.
Davidson, Lee +6 more
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Bitlis Eren Üniversitesi Fen Bilimleri DergisiThis study focused on the discovery of new drug candidates effective against the monkeypox virus. Virtual screening was performed to evaluate the potential of chili pepper natural products against homology-modeled DNA-directed RNA polymerase of the monkeypox virus using molecular docking. Our findings revealed that structurally similar triterpenes such
Özkan Fidan, Somdutt Mujwar
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DNA-directed termination of RNA polymerase II transcription [PDF]
Molecular Cell, 2023 RNA polymerase II (RNAPII) transcription involves initiation from a promoter, transcriptional elongation through the gene, and termination in the terminator region. In bacteria, terminators often contain specific DNA elements provoking polymerase dissociation, but RNAPII transcription termination is thought to be driven entirely by protein co-factors ...
Zhong Han +7 more
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Emerging resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease, continue to plague mankind and reduce the efficacies of antitubercular therapies that have been an effective defence against TB for decades.
Mokgerwa Zacharia Monama
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