Results 201 to 210 of about 186,623 (239)

Incorporation of arabinose-CTP and arabinose-UTP inhibits viral polymerases by inducing long pauses. [PDF]

J Biol Chem
Xiao Z, Das A, Jain A, Anderson TK, Cameron CE, Arnold JJ, Dulin D, Kirchdoerfer RN.   +7 more
europepmc   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Small RNA, big defence: Early epigenetic responses to genetic invasion. [PDF]

Quant Plant Biol
Mun S, Kang YJ, Cho J.
europepmc   +1 more source

SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase

, 2006
Patrick Shiu, Denise Zickler, Namboori B. Raju, Gwenaël Ruprich‐Robert, Robert L. Metzenberg   +4 more
openalex   +2 more sources

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Template nicking suppresses promoter-independent antisense transcription in IVT via R-loop-mediated strand displacement. [PDF]

Nucleic Acids Res
Lee G, Ryu J, Jang J, Noh W, Kim DE.
europepmc   +1 more source

Separation of Ribonuclease H and RNA Directed DNA Polymerase (Reverse Transcriptase) of Murine Type-C RNA Tumor Viruses

, 1974
Alan M. Wu, M. G. Sarngadharan, Robert C. Gallo   +2 more
openalex   +2 more sources

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Phosphorylation Modifications and Their Role in Viral Pneumonia: Mechanisms and Therapeutic Implications. [PDF]

Infect Drug Resist
Wang L, Zhang H, Jiang H.
europepmc   +1 more source