Results 21 to 30 of about 186,623 (239)
Pol IV-Dependent siRNA Production is Reduced in Brassica rapa
Biology, 2013 Plants produce a diverse array of small RNA molecules capable of gene regulation, including Pol IV-dependent short interfering (p4-si)RNAs that trigger transcriptional gene silencing.
Rebecca A. Mosher +2 more
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Scientific Reports, 2022 In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various aqueous solutions. However, substrate specificity is derived from the chemical properties of the residues, which implies that perturbations of ...
Shuntaro Takahashi +5 more
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Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity
Biology, 2012 HIV-1 enzyme reverse transcriptase (RT) is a major target for antiviral drug development, with over half of current FDA-approved therapeutics against HIV infection targeting the DNA polymerase activity of this enzyme. HIV-1 RT is a multifunctional enzyme
Michael A. Parniak +4 more
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On the origin of DNA genomes: evolution of the division of labor between template and catalyst in model replicator systems. [PDF]
PLoS Computational Biology, 2011 The division of labor between template and catalyst is a fundamental property of all living systems: DNA stores genetic information whereas proteins function as catalysts. The RNA world hypothesis, however, posits that, at the earlier stages of evolution,
Nobuto Takeuchi +2 more
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Morphology and Molecular Phylogeny of Pseudocercospora fatouae Associated with Hypophyllous Leaf Mold on Fatoua villosa in Korea [PDF]
한국균학회지, 2023 Dark brown leaf molds growing in a vein-limited pattern have been continuously observed on the lower leaf surface of Fatoua villosa in Korea.
Kui-Jae Lee +5 more
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PLoS Pathogens, 2022 ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is sensed by the innate immune system as well as why it is so virulent remains enigmatic.
Yong Ran +10 more
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PLoS Genetics, 2020 RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences.
Robert M Erdmann, Colette L Picard
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T4 DNA polymerase improves the efficiency of multiple site-directed mutagenesis
Biotechnology & Biotechnological Equipment, 2016 Site-directed mutagenesis (SDM) is a useful tool to study the functions of regulatory sequences of DNA and RNA, and the structures and functions of proteins. Numerous methods have been developed for either single or multiple SDM (MSDM).
Wei Guo +4 more
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Identification of Potential Biomarkers for CAD Using Integrated Expression and Methylation Data
Frontiers in Genetics, 2020 DNA methylation plays an essential role in the pathogenesis of coronary artery disease (CAD) through regulating mRNA expressions. This study aimed to identify hub genes regulated by DNA methylation as biomarkers of CAD.
Xiaokang Zhang +6 more
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A Pol V-mediated silencing, independent of RNA-directed DNA methylation, applies to 5S rDNA. [PDF]
PLoS Genetics, 2009 The plant-specific RNA polymerases Pol IV and Pol V are essential to RNA-directed DNA methylation (RdDM), which also requires activities from RDR2 (RNA-Dependent RNA Polymerase 2), DCL3 (Dicer-Like 3), AGO4 (Argonaute), and DRM2 (Domains Rearranged ...
Julien Douet +2 more
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