Results 171 to 180 of about 3,029,744 (275)

Cluster analysis of selected Mycobacterium species using rifampicin resistance DNA-directed RNA polymerase beta subunit (rpoB) gene

International Journal of Infectious Diseases, 2020
O.S. Amoo, I. Taiwo, F. Anwoju
openaire   +2 more sources

Effect of Some Reductones on DNA and RNA Polymerases’

Activities of DNA-dependent DNA and RNA polymerases were changed, when the primer DNA had been pre-treated with ascorbic acid, 5-methyl-3,4-dihydroxytetrone, scorbamic acid or 5-mercapto-4-hydroxycoumarin. The activity increased or decreased depending on
Fujiki, Hiroaki, 大村, 浩久, Tomita, Yoshifumi, 富田, 純史, Omura, Hirohisa, Shinohara, Kazuki, 篠原, 和毅, 村上, 浩紀, Murakami, Hiroki, 藤木, 博明   +9 more
core  

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Molecular Insights into High-Pathogenicity RNA Viruses. [PDF]

Viruses
Krnjić H, Hrapović A, Galijatović A, Tipura A, Hajdarpašić M, Kozarić S, Berilo A, Odobašić N, Hromić-Jahjefendić A, Šutković J.   +9 more
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Fluorogenic RNA Aptamer-Based Activity Quantification of T7 RNA Polymerase. [PDF]

Biochemistry
Mimouni K, Qiu W, Zhou H.
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Magnesium Concentration Modulates Replication Slippage of Mesophilic and Thermophilic DNA Polymerases In Vitro. [PDF]

Int J Mol Sci
Castillo-Lizardo M, Viguera E.
europepmc   +1 more source

Studies of RNA chain initiation by Escherichia coli RNA polymerase bound to T7 DNA. Direct analysis of the kinetics of RNA chain initiation at T7 promoter A2.

Journal of Biological Chemistry, 1980
W C, Nierman, M J, Chamberlin
openaire   +2 more sources

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source