Results 121 to 130 of about 6,778,475 (339)

Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses [PDF]

, 2020
Martin Kapun, Maite G. Barrón, Fabian Staubach, Darren J. Obbard, R Axel W Wiberg, Jorge Vieira, Clément Goubert, Omar Rota‐Stabelli, Maaria Kankare, María Bogaerts-Márquez, Annabelle Haudry, Lena Waidele, Iryna Kozeretska, E. G. Pasyukova, Volker Loeschcke, Marta Pascual, Cristina P. Vieira, Svitlana Serga, Catherine Montchamp‐Moreau, Jessica K. Abbott, Patricia Gibert, Damiano Porcelli, Nico Posnien, Alejandro Sánchez‐Gracia, Sonja Grath, Élio Sucena, Alan O. Bergland, Maria Pilar García Guerreiro, Banu Şebnem Önder, Eliza Argyridou, Lain Guio, Mads F. Schou, Bart Deplancke, Cristina Vieira, Michael G. Ritchie, Bas J. Zwaan, Eran Tauber, Dorcas J. Orengo, Eva Puerma, Montserrat Aguadé, Paul Schmidt, John Parsch, Andrea J. Betancourt, Thomas Flatt, Josefa González   +44 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

DNA polymerase zeta (pol ζ) in higher eukaryotes [PDF]

, 2007
Gregory N. Gan, John P. Wittschieben, Birgitte Ø. Wittschieben, Richard D. Wood   +3 more
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Sensing viruses by mechanical tension of DNA in responsive hydrogels

, 2013
The rapid worldwide spread of severe viral infections, often involving novel modifications of viruses, poses major challenges to our health care systems. This means that tools that can efficiently and specifically diagnose viruses are much needed.
Cherstvy, Andrey G., Metzler, Ralf, Shin, Jaeoh   +2 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

DNA Barcoding studies on Thrips in India: Cryptic species and Species complexes

Scientific Reports, 2017
Thrips are one of the major sucking pest and vector of plant viruses causing huge economic loss in agriculture. The accurate identification of thrips is crucial for effective pest management strategies.
Kaomud Tyagi, Vikas Kumar, Devkant Singha, Kailash Chandra, Boni Amin Laskar, Shantanu Kundu, Rajasree Chakraborty, Sumantika Chatterjee   +7 more
doaj   +1 more source

How telomere dynamics are influenced by the balance between mitochondrial efficiency, reactive oxygen species production and DNA damage [PDF]

, 2021
Neil B. Metcalfe, Mats Olsson
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The infectivity of AAV9 is influenced by the specific location and extent of chemically modified capsid residues

Journal of Biological Engineering
Background Several treatments for genetic diseases utilizing recombinant adeno-associated viruses (AAVs) have recently gained approval. However, the development of a greater number of therapeutic AAVs is constrained by certain limitations.
Sergio Milagros, Pablo Ramírez-Ruiz de Erenchun, Maite Guembe, Beatriz Carte, Miriam Méndez, Ander Uribarri, Rafael Aldabe   +6 more
doaj   +1 more source