Results 121 to 130 of about 8,837,195 (335)

Single DNA conformations and biological function [PDF]

, 2006
From a nanoscience perspective, cellular processes and their reduced in vitro imitations provide extraordinary examples for highly robust few or single molecule reaction pathways. A prime example are biochemical reactions involving DNA molecules, and the
Ambjoernsson, Tobias, Hanke, Andreas, Levene, Stephen, Metzler, Ralf, Zhang, Yongli   +4 more
core   +2 more sources

Sensing viruses by mechanical tension of DNA in responsive hydrogels

, 2013
The rapid worldwide spread of severe viral infections, often involving novel modifications of viruses, poses major challenges to our health care systems. This means that tools that can efficiently and specifically diagnose viruses are much needed.
Cherstvy, Andrey G., Metzler, Ralf, Shin, Jaeoh   +2 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The infectivity of AAV9 is influenced by the specific location and extent of chemically modified capsid residues

Journal of Biological Engineering
Background Several treatments for genetic diseases utilizing recombinant adeno-associated viruses (AAVs) have recently gained approval. However, the development of a greater number of therapeutic AAVs is constrained by certain limitations.
Sergio Milagros, Pablo Ramírez-Ruiz de Erenchun, Maite Guembe, Beatriz Carte, Miriam Méndez, Ander Uribarri, Rafael Aldabe   +6 more
doaj   +1 more source

Disorder in DNA-Linked Gold Nanoparticle Assemblies

, 2005
We report experimental observations on the effect of disorder on the phase behavior of DNA-linked nanoparticle assemblies. Variation in DNA linker lengths results in different melting temperatures of the DNA-linked nanoparticle assemblies. We observed an
Ching-Hwa Kiang, K. Breslauer, Nolan C. Harris, Y. Sun   +3 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Escuela N°116 "Santiago del Estero"

A&P Continuidad, 2020
Ministerio de Obras Públicas DNA.
doaj   +1 more source

Recurrent de novo mitochondrial DNA mutations in respiratory chain deficiency [PDF]

, 2003
Sophie Lebon, M Chol, P Benit, C Mugnier, D Chretien, I Giurgea, I Kern, E Girardin, L Hertz-Pannier, P de Lonlay, A Rötig, P Rustin, A Munnich   +12 more
openalex   +1 more source

Short Diagnosis-to-Treatment Interval Is Associated With Higher Circulating Tumor DNA Levels in Diffuse Large B-Cell Lymphoma

, 2021
Stefan Alig, Charles Macaulay, David M. Kurtz, Ulrich Dührsen, Andreas Hüttmann, Christine Hanoun, Michael C. Jin, Brian J. Sworder, Andrea Garofalo, Mohammad Shahrokh Esfahani, Barzin Y. Nabet, Joanne Soo, Florian Scherer, Alexander Craig, Olivier Casasnovas, Jason R. Westin, Gianluca Gaïdano, Davide Rossi, Mark Roschewski, Wyndham H. Wilson, Michel Meignan, Maximilian Diehn, Ash A. Alizadeh   +22 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source