Results 181 to 190 of about 3,004,540 (219)

Curcumin Attenuates Aroclor 1254-Induced Oxidative, Genotoxic, and Apoptotic Alterations in HepG2 Cells. [PDF]

J Biochem Mol Toxicol
Erkekoğlu P, Erdemli Köse SB, Tezel Yalçın H, Çakır DA.   +3 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Silver nanoparticle-induced site-specific strand cleavage of chemically modified oligonucleotides for long-chain DNA assembly. [PDF]

Nucleic Acids Res
Inagaki M, Kase M, Hiraoka H, Oka N, Hashiya F, Abe N, Kimura Y, Abe H.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Caveat emptor: predicting and modeling protein-DNA recognition and binding via machine-learning computational approaches. [PDF]

Nucleic Acids Res
Esler MA, Werther R, Doyle LA, Ubilla-Rodriguez NC, Schwensen JS, Hallinan JP, Lambert AR, Young JC, Silverstein M, Stoddard BL.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

P849: iSWAB-DNA: A long-term buccal sample collection device that preserves high-quality DNA at room temperature and challenges transportation conditions.

Genetics in Medicine Open
Vy Lam, Ying Wang
doaj   +1 more source

Structural insights into HSV-1 origin unwinding by the viral proteins UL9 and ICP8. [PDF]

Nucleic Acids Res
Baranovskiy AG, Morstadt LM, Romero EE, Babayeva ND, Tahirov TH.   +4 more
europepmc   +1 more source

Quantitative analysis of sequential nucleic acid elution from silica paramagnetic beads.

Analyst
Varon A, Schares J, Hsieh K, Downs B, Wang TH.   +4 more
europepmc   +1 more source