Results 221 to 230 of about 8,718,410 (331)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Smart nanofluidic systems powered by DNA origami for targeted intracellular delivery: a newer approach. [PDF]

Explor Target Antitumor Ther
Singh D, Singh S, Tandon N, Bedi N.
europepmc   +1 more source

DNA lesion-gated dumbbell nanodevices enable on-demand activation of the cGAS-STING pathway for enhancing cancer immunotherapy

Mei-Ling Zhao, Yan‐Mei Lei, Jingyi Tang, Wen Li, Xinyu Cao, Wenbin Liang, Ruo Yuan, Chaoyong Yang, Ying Zhuo   +8 more
openalex   +1 more source

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching

, 2019
Masataka Tsuda, Saki Ogawa, Masato Ooka, Kaori Kobayashi, Kouji Hirota, Mitsuo Wakasugi, Tsukasa Matsunaga, Tetsushi Sakuma, Takashi Yamamoto, Shunsuke Chikuma, Hiroyuki Sasanuma, Michelle Debatisse, Aidan J. Doherty, Robert P. Fuchs, Shunichi Takeda   +14 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Structural basis of Nuclear Factor 1-X DNA recognition provides prototypic insight into the NFI family. [PDF]

Nat Commun
Tiberi M, Lapi M, Gourlay LJ, Chaves-Sanjuan A, Polentarutti M, Demitri N, Cavinato M, Bonnet DMV, Taglietti V, Righetti A, Sala R, Cauteruccio S, Kumawat A, Russo R, Barbiroli AG, Gnesutta N, Camilloni C, Bolognesi M, Messina G, Nardini M.   +19 more
europepmc   +1 more source

The relationship between nuclear DNA fragmentation, mitochondrial DNA damage and standard sperm parameters in human spermatozoa of fertile and subfertile men before and after freeze-thaw procedure [PDF]

, 2011
Mohamad Eid Hammadeh, H. Fawaz, Erich‐Franz Solomayer   +2 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation. [PDF]

World J Psychiatry
Huang XL, Chen DF, Wang Y, Zhang YN, Michael N, Ge YS, Wang B.   +6 more
europepmc   +1 more source

Orientation of Pseudomonas aeruginosa ExsA Monomers Bound to Promoter DNA and Base-Specific Contacts with the PexoT Promoter

, 2012
J. M. King, E. D. Brutinel, Anne E. Marsden, Florian D. Schubot, Timothy L. Yahr   +4 more
openalex   +2 more sources