Results 221 to 230 of about 6,079,340 (257)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Eosinophil extracellular traps: heterogeneity of their stimuli, components, and functions. [PDF]

Trends Cell Biol
Zhang J, Liu X, Shi GP, Chen W, Zhang S.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review. [PDF]

Epigenetics
Jiang ZH, Wang DF, Shao R, Wang XS, Tang ZR.   +4 more
europepmc   +1 more source

Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry. [PDF]

Nucleic Acids Res
Chin D, Luo Y, Lau Y, Dutta N, He Z, Yin C, Williams RM, Balachandran S, Vicens Q, Dröge P, Luo D.   +10 more
europepmc   +1 more source

Differential DNA methylation clock ages across buffy coat (BC), peripheral blood mononuclear cells (PBMC), and saliva in individuals in early-to-mid adulthood. [PDF]

Epigenetics
Bruellman R, Evans D, Smolen A, Evans LM, Reynolds CA.   +4 more
europepmc   +1 more source

A report of novel inactivating missense mutations of BRCA1 detected in patients with acute myeloid leukemia. [PDF]

J Med Case Rep
Ejaz S, Raashid A, Hameed Y, Abdullah I, Imtiaz N, Iqbal M, Khurshid M, Malik WN.   +7 more
europepmc   +1 more source

Swabbing as a Non-Lethal DNA Collection Method for Earthworm Barcoding: Performance and Citizen Science Perspectives. [PDF]

Ecol Evol
Amirhosseini K, Müller M, Potthoff M, Gailing O.   +3 more
europepmc   +1 more source