Results 291 to 300 of about 7,795,985 (403)

Germline variants in CDKN2A wild‐type melanoma prone families

open access: yesMolecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen   +5 more
wiley   +1 more source

Junk DNA: "DNA zabor" ala "DNA txatar"?

open access: yes, 2013
Funtzio ezagunik edo argirik ez duen genomaren zatia DNA zabor bezala ezagutzen da. DNA zaborra eratzen duten osagaiak gehiago ikertzen goazen heinean, osagai hauek genometan izan dezaketen garrantzia ere azaleratzen doa. Era berean, hain garrantzia handia egozten ez dioten aurkikuntzak ere egin dira.
openaire   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications. [PDF]

open access: yesJ Nanobiotechnology
Acharya R   +10 more
europepmc   +1 more source

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