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Forensic Science, Medicine, and Pathology, 2007
The rapid development, success, and occasional failures of forensic DNA profiling are highly publicised, and as a consequence are well known to the scientific and public communities alike. Over the same period of time that forensic DNA typing has accelerated onto the scene, another related discipline has been born and has made equally, or perhaps, even
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The rapid development, success, and occasional failures of forensic DNA profiling are highly publicised, and as a consequence are well known to the scientific and public communities alike. Over the same period of time that forensic DNA typing has accelerated onto the scene, another related discipline has been born and has made equally, or perhaps, even
openaire +3 more sources
DNA Glycosylases in DNA Repair [PDF]
, 1986 The excision of potentially mutagenic and lethal lesions from DNA proceeds by one of two different routes. DNA damage which results in a major distortion of the DNA double-helix is generally recognized by a high-molecular weight nuclease that cuts two phosphodiester bonds in the altered strand, one on each side of the lesion.
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2000
Recently, the requirement for gene diagnosis has increased as the number of causal genes that have been found has increased. There are ethical problems, yet gene therapy has been popular. Medical treatments have been intimately connected with genetics. Here BIACORE applications in the medical field are also described beside mismatch detection.
Mariko Tosu, Masanori Gotoh
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Recently, the requirement for gene diagnosis has increased as the number of causal genes that have been found has increased. There are ethical problems, yet gene therapy has been popular. Medical treatments have been intimately connected with genetics. Here BIACORE applications in the medical field are also described beside mismatch detection.
Mariko Tosu, Masanori Gotoh
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DNA Gyrase and the Supercoiling of DNA
Science, 1980Negative supercoiling of bacterial DNA by DNA gyrase influences all metabolic processes involving DNA and is essential for replication. Gyrase supercoils DNA by a mechanism called sign inversion, whereby a positive supercoil is directly inverted to a negative one by passing a DNA segment through a transient double-strand break.
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Biopolymers, 2004
AbstractTargeting double‐stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA‐PNA chimeras. A 16‐mer 5′‐DNA‐3′‐p‐(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and ...
PETRACCONE, LUIGI +7 more
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AbstractTargeting double‐stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA‐PNA chimeras. A 16‐mer 5′‐DNA‐3′‐p‐(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and ...
PETRACCONE, LUIGI +7 more
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Eukaryotic DNA polymerases in DNA replication and DNA repair
Chromosoma, 1998DNA polymerases carry out a large variety of synthetic transactions during DNA replication, DNA recombination and DNA repair. Substrates for DNA polymerases vary from single nucleotide gaps to kilobase size gaps and from relatively simple gapped structures to complex replication forks in which two strands need to be replicated simultaneously ...
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2010
There are few scientific approaches to human identification that are more effective than a well-trained forensic dentist armed with a set of high-quality dental records and radiographs. Fingerprinting is probably the only other technique used with greater frequency, but as we know, the soft tissue of the extremities does not resist the ravages of ...
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There are few scientific approaches to human identification that are more effective than a well-trained forensic dentist armed with a set of high-quality dental records and radiographs. Fingerprinting is probably the only other technique used with greater frequency, but as we know, the soft tissue of the extremities does not resist the ravages of ...
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The Detection of Anti-Dna and Dna/Anti-Dna Complexes
Scandinavian Journal of Rheumatology, 1975(1975). The Detection of Anti-Dna and Dna/Anti-Dna Complexes. Scandinavian Journal of Rheumatology: Vol. 4, No. sup11, pp. 7-11.
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DNA Labeling Using DNA Methyltransferases
2016DNA methyltransferases (MTases) uniquely combine the ability to recognize and covalently modify specific target sequences in DNA using the ubiquitous cofactor S-adenosyl-L-methionine (AdoMet). Although DNA methylation plays important roles in biological signaling, the transferred methyl group is a poor reporter and is highly inert to further ...
Tomkuvienė, Miglė +2 more
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DNA Methyltransferases and DNA Damage
2022Ever since the discovery of depletion of CG sites in mammalian genomes it has been clear that cytosine DNA methyltransferases (DNMTs) are linked to the rate at which mutations accumulate in DNA. Research in the intervening decades has shown that DNMTs influence mutation rates through the indirect consequences of methylation on the mechanism of mutation
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