Results 371 to 380 of about 7,795,985 (403)
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Annual Review of Biochemistry, 1981
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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Current Protocols in Molecular Biology, 2008
AbstractThis unit presents characteristics and reaction conditions of the DNA‐dependent DNA polymerases, including E. coli DNA polymerase I and its Klenow fragment, T4 DNA polymerase, native and modified T7 DNA polymerase, phi29 DNA polymerase, Bst DNA polymerase, and Taq DNA polymerase. The unit also provides overviews of other classes of thermophilic
Rebecca Kucera, Nicole M. Nichols
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AbstractThis unit presents characteristics and reaction conditions of the DNA‐dependent DNA polymerases, including E. coli DNA polymerase I and its Klenow fragment, T4 DNA polymerase, native and modified T7 DNA polymerase, phi29 DNA polymerase, Bst DNA polymerase, and Taq DNA polymerase. The unit also provides overviews of other classes of thermophilic
Rebecca Kucera, Nicole M. Nichols
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Science, 1990
High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand selection from pools of variant sequences and amplification of the bound species. Multiple rounds exponentially enrich the population
C. Tuerk, L. Gold
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High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand selection from pools of variant sequences and amplification of the bound species. Multiple rounds exponentially enrich the population
C. Tuerk, L. Gold
semanticscholar +1 more source
DNA Methylation and DNA Structure
1984Novel DNA substrates, such as hemimethylated DNA, supercoiled, partially or fully relaxed DNA, either intact or UV-irradiated, have been used to study either some aspects of the mechanism of DNA methylation or some aspects of the effect of pathological and physiological DNA methylation on DNA conformation.
A. Rebuzzini +5 more
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Forensic Science, Medicine, and Pathology, 2007
The rapid development, success, and occasional failures of forensic DNA profiling are highly publicised, and as a consequence are well known to the scientific and public communities alike. Over the same period of time that forensic DNA typing has accelerated onto the scene, another related discipline has been born and has made equally, or perhaps, even
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The rapid development, success, and occasional failures of forensic DNA profiling are highly publicised, and as a consequence are well known to the scientific and public communities alike. Over the same period of time that forensic DNA typing has accelerated onto the scene, another related discipline has been born and has made equally, or perhaps, even
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DNA Glycosylases in DNA Repair [PDF]
, 1986 The excision of potentially mutagenic and lethal lesions from DNA proceeds by one of two different routes. DNA damage which results in a major distortion of the DNA double-helix is generally recognized by a high-molecular weight nuclease that cuts two phosphodiester bonds in the altered strand, one on each side of the lesion.
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Biochemistry and Molecular Biology Education, 2023
AbstractThis year marks 70 years since the discovery of DNA, and this poem “DNA” is an attempt to make the general audience aware of the basic features of this macromolecule.
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AbstractThis year marks 70 years since the discovery of DNA, and this poem “DNA” is an attempt to make the general audience aware of the basic features of this macromolecule.
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2000
Recently, the requirement for gene diagnosis has increased as the number of causal genes that have been found has increased. There are ethical problems, yet gene therapy has been popular. Medical treatments have been intimately connected with genetics. Here BIACORE applications in the medical field are also described beside mismatch detection.
Mariko Tosu, Masanori Gotoh
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Recently, the requirement for gene diagnosis has increased as the number of causal genes that have been found has increased. There are ethical problems, yet gene therapy has been popular. Medical treatments have been intimately connected with genetics. Here BIACORE applications in the medical field are also described beside mismatch detection.
Mariko Tosu, Masanori Gotoh
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A Greedy Algorithm for Aligning DNA Sequences
J. Comput. Biol., 2000For aligning DNA sequences that differ only by sequencing errors, or by equivalent errors from other sources, a greedy algorithm can be much faster than traditional dynamic programming approaches and yet produce an alignment that is guaranteed to be ...
Zheng Zhang +3 more
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DNA Gyrase and the Supercoiling of DNA
Science, 1980Negative supercoiling of bacterial DNA by DNA gyrase influences all metabolic processes involving DNA and is essential for replication. Gyrase supercoils DNA by a mechanism called sign inversion, whereby a positive supercoil is directly inverted to a negative one by passing a DNA segment through a transient double-strand break.
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