Results 1 to 10 of about 2,144,108 (379)
Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor [PDF]
Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA ...
Kazuhiro Shiizaki+2 more
doaj +3 more sources
Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme [PDF]
Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severely ...
Yi Xiao+9 more
doaj +2 more sources
Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct [PDF]
Benzo[a]pyrene (B[a]P), a group 1 carcinogen, induces mutagenic DNA adducts. Myricetin is present in many natural foods with diverse biological activities, such as anti-oxidative and anti-cancer activities.
Seung-Cheol Jee+4 more
doaj +2 more sources
DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication.
T R Rajalakshmi+3 more
doaj +4 more sources
Biomarker-based evaluation of aflatoxin B1 exposure in cattle [PDF]
Background and Aim: Assessment of aflatoxin B1 (AFB1) exposure in cattle traditionally relies on feed analysis, which may not reflect chronic exposure or accurately indicate individual susceptibility.
Priyadharshini Ponnusamy+8 more
doaj +2 more sources
Analysis of Novel DNA Adducts Derived from Acetaldehyde [PDF]
Alcohol consumption is a known risk factor for esophageal and liver cancers. Recently, it was reported that mutation signatures characterized by T:A to C:G mutations (SBS16), which are suggested to be associated with alcohol intake, are frequently ...
Yuuki Betsuyaku+4 more
doaj +2 more sources
Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
doaj +1 more source
Numerous human and animal studies have reported positive correlation between carcinogen-DNA adduct levels and cancer occurrence. Therefore, attenuation of DNA adduct levels would be expected to suppress tumorigenesis.
Guodong Zhou+6 more
doaj +1 more source
Flipping Back of Extrahelical Guanine after Methyl Repair
Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Rajendra Prasad Koirala+1 more
doaj +3 more sources
Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde.
Zhijun Zhang+3 more
doaj +1 more source