Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme [PDF]
Bioactive Materials, 2023 Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severely ...
Yi Xiao +9 more
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Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct [PDF]
Antioxidants, 2020 Benzo[a]pyrene (B[a]P), a group 1 carcinogen, induces mutagenic DNA adducts. Myricetin is present in many natural foods with diverse biological activities, such as anti-oxidative and anti-cancer activities.
Seung-Cheol Jee +4 more
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Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor [PDF]
Genes and Environment, 2017 Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA ...
Kazuhiro Shiizaki +2 more
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Journal of Pharmacy and Bioallied Sciences, 2015 DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication.
T R Rajalakshmi +3 more
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Multi-DNA Adduct and Abasic Site Quantitation In Vivo by Nano-Liquid Chromatography/High-Resolution Orbitrap Tandem Mass Spectrometry: Methodology for Biomonitoring Colorectal DNA Damage. [PDF]
Chem Res Toxicol, 2022 Konorev D, Yao L, Turesky RJ.
europepmc +3 more sources
Recognition and Sequencing of Mutagenic DNA Adduct at Single-Base Resolution Through Unnatural Base Pair. [PDF]
Adv Sci (Weinh)Wang H +8 more
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Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer. [PDF]
J Biol Chem, 2017 Minko IG, Rizzo CJ, Lloyd RS.
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Translocation of benzo(a)pyrene reactive metabolites across human mammary epithelial cell membranes. [PDF]
PLoS ONEDNA adducts from benzo(a)pyrene (BaP) and other polycyclic aromatic hydrocarbons (PAH) are related to tumor initiation in many tissues including mammary epithelia.
B Alex Merrick +4 more
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Ecotoxicology and Environmental SafetyDNA adducts, formed by the covalent binding of reactive electrophiles to DNA, serve as biomarkers of genotoxic exposure and early biological effects. However, non-invasive, high-throughput biomonitoring methods remain underdeveloped. This study developed
Bo-Ri Kim +9 more
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Toxics, 2022 Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
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