Results 1 to 10 of about 33,588 (237)
Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme [PDF]
Bioactive Materials, 2023 Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severely ...
Yi Xiao +9 more
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Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct [PDF]
Antioxidants, 2020 Benzo[a]pyrene (B[a]P), a group 1 carcinogen, induces mutagenic DNA adducts. Myricetin is present in many natural foods with diverse biological activities, such as anti-oxidative and anti-cancer activities.
Seung-Cheol Jee +4 more
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Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor [PDF]
Genes and Environment, 2017 Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA ...
Kazuhiro Shiizaki +2 more
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Journal of Pharmacy and Bioallied Sciences, 2015 DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication.
T R Rajalakshmi +3 more
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Translocation of benzo(a)pyrene reactive metabolites across human mammary epithelial cell membranes. [PDF]
PLoS ONEDNA adducts from benzo(a)pyrene (BaP) and other polycyclic aromatic hydrocarbons (PAH) are related to tumor initiation in many tissues including mammary epithelia.
B Alex Merrick +4 more
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Toxics, 2022 Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
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Antioxidants, 2022 Numerous human and animal studies have reported positive correlation between carcinogen-DNA adduct levels and cancer occurrence. Therefore, attenuation of DNA adduct levels would be expected to suppress tumorigenesis.
Guodong Zhou +6 more
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Flipping Back of Extrahelical Guanine after Methyl Repair
Bibechana, 2022 Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Rajendra Prasad Koirala +1 more
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Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
Scientific Reports, 2023 To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde.
Zhijun Zhang +3 more
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Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study
Bibechana, 2022 Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Bibek Subedi, Narayan Adhikari
doaj +3 more sources