Results 1 to 10 of about 2,144,108 (379)

Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor [PDF]

Genes and Environment, 2017
Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA ...
Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi   +2 more
doaj   +3 more sources

Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme [PDF]

Bioactive Materials, 2023
Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severely ...
Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye   +9 more
doaj   +2 more sources

Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct [PDF]

Antioxidants, 2020
Benzo[a]pyrene (B[a]P), a group 1 carcinogen, induces mutagenic DNA adducts. Myricetin is present in many natural foods with diverse biological activities, such as anti-oxidative and anti-cancer activities.
Seung-Cheol Jee, Min Kim, Kyeong Seok Kim, Hyung-Sik Kim, Jung-Suk Sung   +4 more
doaj   +2 more sources

DNA adducts-chemical addons

Journal of Pharmacy and Bioallied Sciences, 2015
DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication.
T R Rajalakshmi, N AravindhaBabu, K T Shanmugam, K. M. K. Masthan   +3 more
doaj   +4 more sources

Biomarker-based evaluation of aflatoxin B1 exposure in cattle [PDF]

Veterinary World
Background and Aim: Assessment of aflatoxin B1 (AFB1) exposure in cattle traditionally relies on feed analysis, which may not reflect chronic exposure or accurately indicate individual susceptibility.
Priyadharshini Ponnusamy, Umaya Suganthi Rajendran, Madhavan Gopalakrishnan Nair, Uma Sambath, Raja Kumar, Jacob Thanislass, Avinash Warundeo Lakkawar, Vijayalakshmi Padmanaban, Poobitha Subbarayan   +8 more
doaj   +2 more sources

Analysis of Novel DNA Adducts Derived from Acetaldehyde [PDF]

Biomolecules
Alcohol consumption is a known risk factor for esophageal and liver cancers. Recently, it was reported that mutation signatures characterized by T:A to C:G mutations (SBS16), which are suggested to be associated with alcohol intake, are frequently ...
Yuuki Betsuyaku, Mina Motohashi, Akira Sassa, Takeji Takamura-Enya, Yukari Totsuka   +4 more
doaj   +2 more sources

Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts

Toxics, 2022
Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
doaj   +1 more source

Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary DNA Adducts and Cytochrome P450 (CYP)1B1 by Dietary Antioxidants, Omega-3 Fatty Acids, in Mice

Antioxidants, 2022
Numerous human and animal studies have reported positive correlation between carcinogen-DNA adduct levels and cancer occurrence. Therefore, attenuation of DNA adduct levels would be expected to suppress tumorigenesis.
Guodong Zhou, Weiwu Jiang, Guobin Xia, Lihua Wang, Molly Richardson, Chun Chu, Bhagavatula Moorthy   +6 more
doaj   +1 more source

Flipping Back of Extrahelical Guanine after Methyl Repair

Bibechana, 2022
Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Rajendra Prasad Koirala, Narayan Prasad Adhikari   +1 more
doaj   +3 more sources

Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde

Scientific Reports, 2023
To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde.
Zhijun Zhang, Yuan Yang, Changjun Hu, Zaiqi Zhang   +3 more
doaj   +1 more source