Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum-Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects. [PDF]
Int J Mol Sci, 2021 Hreusova M, Brabec V, Novakova O.
europepmc +1 more source
Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats. [PDF]
Int J Mol Sci, 2021 Bárta F +8 more
europepmc +1 more source
Helvetica Chimica Acta, EarlyView.ABSTRACT This study presents a high‐throughput ion mobility approach that integrates flow injection analysis (FIA) with multiple stitched high‐resolution ion mobility ranges to enable comprehensive analysis of human milk oligosaccharide (HMO) isomer mixtures in a single acquisition.
Wenqing Xu +5 more
wiley +1 more source
Streamlined Synthesis of Triamantane from Readily Available Starting Materials
Helvetica Chimica Acta, EarlyView.A practical laboratory synthesis of triamantane based on the McKervey modification of the Schleyer stabilomeric synthesis is described. A high‐yielding rearrangement of Binor‐S and a significantly facilitated Diels–Alder step allowed an operationally simple sequence that reliably delivers triamantane on a tens‐of‐grams scale.
Xiao‐Yu Li, Christof Sparr
wiley +1 more source
Toxics1,3-butadiene (BD) is a volatile organic pollutant. Upon inhalation, it is metabolically activated to reactive epoxides which alkylate genomic DNA and form potentially mutagenic monoadducts and DNA–DNA crosslinks including N7-(1-hydroxyl-3-buten-1-yl ...
Erik Moran +5 more
doaj +1 more source
The lipid peroxidation derived DNA adduct γ-OHPdG levels in paraneoplastic liver tissues predict postoperative outcomes of hepatoma. [PDF]
J Cancer, 2021 Feng YY, Yu J, Huang YH, Lin YH, Yeh CT.
europepmc +1 more source
Plasmonic Heterojunction Nanomaterials for Noninvasive Pan‐Cancer Metabolomic Screening
Interdisciplinary Materials, EarlyView.This study develops gold nanoparticle‐modified manganese–cobalt oxide heterjunctions (Au/MCOM) as a laser desorption/ionization mass spectrometry (LDI‐MS) matrix for acquiring serum metabolic fingerprints. Combined with machine learning, the platform achieves accurate detection and early screening across six cancer types, demonstrating strong potential
Jia Qi +5 more
wiley +1 more source
Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models. [PDF]
Mutagenesis, 2021 Downs TR +4 more
europepmc +1 more source
International Journal of Cancer, EarlyView.What's New? While the association between tobacco consumption and oral cancer is well established, the effect of cessation, particularly of chewing tobacco, the most common tobacco product in South Asia, is understudied. This case–control study in an Indian population demonstrates that a longer duration of tobacco smoking and chewing cessation is ...
Gayathri B. Pullat +8 more
wiley +1 more source
Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N2-ethenodeoxyguanosine by human DNA translesion polymerase η. [PDF]
J Biol Chem, 2021 Ghodke PP +5 more
europepmc +1 more source