Results 101 to 110 of about 2,144,108 (379)

Metabolic activation and DNA adduct formation of Benzo(a) pyrene by adult and newborn rat skin and liver microsomes [PDF]

open access: yesJournal of Kerman University of Medical Sciences, 2000
Benzo(a) pyrene is a carcinigen polycyclic aromatic hydrocarbon which diffuses into the environment from combustion of organic meterials.based on various epidemiological evidences it is related to lung,skin and liver cancer.mutagenicity,and ...
M Mohammadi, A.A Alameh, M.R Nori-Daloii
doaj  

Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest. [PDF]

open access: yesPLoS ONE, 2017
The efficacy of cisplatin-based chemotherapy in cancer is limited by the occurrence of innate and acquired drug resistance. In order to better understand the mechanisms underlying acquired cisplatin resistance, we have compared the adenocarcinoma-derived
Navin Sarin   +10 more
doaj   +1 more source

32P-Postlabeling of a DNA adduct derived from 4,4′-methylenedianiline, in the olfactory epithelium of rats exposed by inhalation to 4,4′-methylenediphenyl diisocyanate [PDF]

open access: yes, 2017
Tissues obtained from female Wistar rats exposed to a 0.9 μm aerosol of 4,4′-methylenediphenyl diisocyanate (MDI) for 17 h per day, 5 days per week, for one year, at levels of 0, 0.3, 0.7 and 2.0 mg/m3, were analyzed for DNA adducts.
Heinrich, U.   +3 more
core  

Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts [PDF]

open access: yes, 2013
Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side-effects. Photoactivatable PtIV prodrugs offer the potential of targeted drug release and new mechanisms of action.
Bancroft   +57 more
core   +1 more source

The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk.

open access: yesCarcinogenesis, 2002
The DNA repair protein xeroderma pigmentosum complementation group D (XPD) is involved in the nucleotide excision repair of DNA lesions induced by many tobacco and environmental carcinogens.
S. Hou   +6 more
semanticscholar   +1 more source

Label‐Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening

open access: yesAdvanced Science, EarlyView.
A label‐free organoid photoacoustic imaging (LFOPI) system is developed for precise volumetric drug screening evaluation. As a proof of concept, LFOPI's performance in chemotherapy and immunotherapy drug screening assays are further evaluated. The LFOPI offers unique non‐invasive, label‐free capabilities for tumor organoids, and contributes to the ...
Xiaofei Luo   +18 more
wiley   +1 more source

Effect of supplemental lactic acid bacteria on growth performance, glutathione turnover and aflatoxin B1 removal in lambs

open access: yesCzech Journal of Animal Science, 2019
This study investigated the effect of lactic acid bacteria (LAB) on growth performance, glutathione turnover, aflatoxin B1 (AFB1) residue and AFB1-DNA adduct in growing lambs.
Jianping Wang   +4 more
doaj   +1 more source

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

open access: yes, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
Alejandro González-Cantó   +78 more
core   +5 more sources

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

open access: yesAdvanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li   +11 more
wiley   +1 more source

Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk.

open access: yesCancer Research, 2006
Red meat is associated with increased risk of colorectal cancer and increases the endogenous formation of N-nitrosocompounds (NOC). To investigate the genotoxic effects of NOC arising from red meat consumption, human volunteers were fed high (420 g) red ...
M. H. Lewin   +7 more
semanticscholar   +1 more source

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