Results 121 to 130 of about 2,144,108 (379)

Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity [PDF]

, 2012
The synthesis and characterization of complexes [(η6-arene)Ru(N,N′)X][PF6], where arene is para-cymene (p-cym), biphenyl (bip), ethyl benzoate (etb), hexamethylbenzene (hmb), indane (ind) or 1,2,3,4-tetrahydronaphthalene (thn), N,N′ is 2,2′-bipyrimidine (
Betanzos-Lara, Soledad, Brabec, V. (Viktor), Clarkson, Guy J., Deeth, Robert J., Habtemariam, Abraha, Liskova, Barbora, Novakova, Olga, Pizarro, Ana M., Sadler, P. J.   +8 more
core   +1 more source

DNA Adducts with Lipid Peroxidation Products [PDF]

Journal of Biological Chemistry, 2008
Homolytic decomposition of PUFA2-derived lipid hydroperoxides results in formation of the α,β-unsaturated aldehydic bifunctional electrophiles DDE, EDE, HNE, HPNE, MDA (shown as β-hydroxyacrolein), ONE, DODE, and 5,8-dioxo-(10E)-octenoic acid (see Fig. 1) (1–3).
openaire   +3 more sources

Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent

Nucleic Acids Research, 2007
Mitoxantrone is an anti-cancer agent used in the treatment of breast and prostate cancers. It is classified as a topoisomerase II poison, however can also be activated by formaldehyde to generate drug–DNA adducts.
Benny J. Evison, O. Mansour, E. Menta, D. Phillips, S. Cutts   +4 more
semanticscholar   +1 more source

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source

Self‐Assembly of a Customizable Library of Nickel Trifluoromethylation Catalysts via Selective C─F and C─O Bond Cleavage

Angewandte Chemie, EarlyView.
Carbatranes and anionic pincer ligands were self‐assembled via one‐pot C─F or C─O bond cleavage and the formation of C─O, C─N, or C─C bonds, forming ligand architectures inaccessible by common synthetic methods. This approach allowed to build a customizable library of nickel catalysts for light‐induced C─H bond trifluoromethylation.
Aleksandr Sorvanov, Shubham Deolka, Eugene Khaskin, Robert R. Fayzullin, Serhii Vasylevskyi, Julia R. Khusnutdinova   +5 more
wiley   +2 more sources

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. [PDF]

, 2017
Pericyclic reactions-which proceed in a concerted fashion through a cyclic transition state-are among the most powerful synthetic transformations used to make multiple regioselective and stereoselective carbon-carbon bonds.
Chen, Mengbin, Hai, Yang, Houk, KN, Liu, Fang, Ohashi, Masao, Sato, Michio, Tang, Man-Cheng, Tang, Yi, Watanabe, Kenji, Yang, Zhongyue   +9 more
core   +1 more source

Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation.

Carcinogenesis, 2007
Polycyclic aromatic hydrocarbons (PAHs) cover a wide range of structurally related compounds which differ greatly in their carcinogenic potency. PAH exposure usually occurs through mixtures rather than individual compounds. Therefore, we assessed whether
Y. Staal, D. Hebels, M. V. van Herwijnen, Ralph W. H. Gottschalk, F. V. van Schooten, J. V. van Delft   +5 more
semanticscholar   +1 more source

Amplifying Anti‐Tumor Immune Responses via Mitochondria‐Targeting Near‐Infrared Photodynamic Therapy

Advanced Science, EarlyView.
Interfacial Nd3+‐triplet energy transfer enables direct activation of molecular triplets under near‐infrared (NIR) irradiation for reactive oxygen species (ROS) generation. Photodynamic therapy (PDT) exaggerates hypoxia, which initiates subsequent hypoxia‐activated chemotherapy.
Cheng‐Ao Li, Junjie Nan, Qingxuan Ye, Bingzhu Zheng, Xiaomeng Dai, Jingya Li, Feng Wang, Huimin Ma, Yu Cheng, Jian Ruan, Weijia Fang, Peng Zhao, Renren Deng, Dong Cen   +13 more
wiley   +1 more source

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

Journal of Nucleic Acids, 2010
DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DNAPs, which are mostly in the Y-Family. Y-Family DNAPs can do non-mutagenic or mutagenic dNTP insertion, and understanding this difference is important ...
Sushil Chandani, Christopher Jacobs, Edward L. Loechler   +2 more
doaj   +1 more source

The lipid peroxidation-derived DNA adduct γ-OHPdG as a diagnostic and prognostic biomarker in hepatocellular carcinoma. [PDF]

Aging (Albany NY), 2023
Cao Q, Zhang Y, Liu H, Cheng Y, Liu M, Zhao H, Tang R, Sun J, Xu S, Sun B, Sun Q.   +10 more
europepmc   +1 more source