Results 131 to 140 of about 40,057 (283)

HMGB1 Assists in Overcoming Cisplatin Resistance in Chemoresistant Human Ovarian Cancer Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of ovarian cancer. However, the frequent development of cisplatin resistance remains a significant limitation, leading to therapeutic failure and poor patient outcomes.
Van Huynh, Guliang Wang, Anirban Mukherjee, Karen M. Vasquez   +3 more
wiley   +1 more source

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry [PDF]

, 2019
Angger Waspodo Dias Adrianto, Bambang Tri Hartomo, Nurtami Soedarsono, Elza Ibrahim Auerkari   +3 more
openalex   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Interindividual Differences in DNA Adduct Formation and Detoxification of 1,3-Butadiene-Derived Epoxide in Human HapMap Cell Lines. [PDF]

Chem Res Toxicol, 2020
Degner A, Arora R, Erber L, Chao C, Peterson LA, Tretyakova NY.   +5 more
europepmc   +1 more source

7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection.

, 1988
J W Park, B N Ames
openalex   +2 more sources

Lipid peroxidation-induced DNA adducts in human gastric mucosa [PDF]

, 2012
Tomonari Matsuda, Han Tao, Masanori Goto, Hidetaka Yamada, Masaru Suzuki, Yulin Wu, Nong Xiao, Qi He, Wenwen Guo, Zhongli Cai, Nobuya Kurabe, Keiko Ishino, Yoshitaka Matsushima, Kazuya Shinmura, Hiroyuki Konno, Masato Maekawa, Yuang Wang, Haruhiko Sugimura   +17 more
openalex   +1 more source

In-vitro STUDY OF ACRYLAMIDE AND TBHQ COMPOUNDS ON THE GENERATION OF DNA ADDUCT 8-HYDROXY-2’- DEOXYGUANOSINE AS BIOMARKER OF OXIDATIVE DNA DAMAGE

, 2022
B. Budiawan, Intan Cahaya Dani, Sri Handayani, Sunardi Sunardi   +3 more
openalex   +1 more source