Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues. [PDF]
Proc Natl Acad Sci U S A, 2018 Yang Y +8 more
europepmc +1 more source
Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 846-858, April 2026.Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic +4 more
wiley +1 more source
An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice. [PDF]
Hepatology, 2018 Fu Y +15 more
europepmc +1 more source
International Journal of Cancer, Volume 158, Issue 7, Page 1821-1835, 1 April 2026.What's new? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman +7 more
wiley +1 more source
Anomeric Amides: Valuable Reagents in Synthetic Organic Chemistry
Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.Enabling late‐stage transformations and skeletal editing, anomeric amides have recently emerged as powerful synthetic tools. Due to their unique properties, anomeric amides have been employed in reactions ranging from amination to halogenation. This minireview provides an overview of recent progress in using anomeric amides across a variety of ...
Arushi Garg +3 more
wiley +2 more sources
Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung. [PDF]
Anal Chem, 2017 Villalta PW, Hochalter JB, Hecht SS.
europepmc +1 more source
The return of metabolism: biochemistry and physiology of glycolysis
Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning +19 more
wiley +1 more source
Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct. [PDF]
J Biol Chem, 2018 Yoon JH +6 more
europepmc +1 more source
Immunology, Volume 177, Issue 4, Page 736-748, April 2026.A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley +1 more source
Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity. [PDF]
Chem Res Toxicol, 2015 Jiang S +7 more
europepmc +1 more source