ChemBioChem, EarlyView.Glutathione‐functionalized gold nanoparticles are shown to reduce radicals in SH‐SY5Y and C6 cells. Conjugation of galactose to the outer shell improves internalization through the GLUT transporter, thus providing a smart multivalent system able to reduce oxidative stress in neuroblastoma and rat glioma cells.
Francesca Milano +6 more
wiley +1 more source
Measurement of chromosomal aberrations, sister chromatid exchange, hprt mutations, and DNA adducts in peripheral lymphocytes of human populations at increased risk for cancer [PDF]
, 1993 David Jacobson‐Kram +15 more
openalex +1 more source
Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx. [PDF]
, 2019 Squamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene mutations which divert cell fate from differentiation to proliferation ...
Curry, Joseph +9 more
core +1 more source
Linking DNA adduct formation and human cancer risk in chemical carcinogenesis
Environmental and Molecular Mutagenesis, 2016 M. Poirier
semanticscholar +1 more source
ChemBioChem, EarlyView.A unique chemoenzymatic synthesis route toward (S)‐baclofen is presented, which highlights a hydroformylation and biocatalysis step toward the synthesis of such a challenging β‐chiral amino acid. The shown methodology exhibits high conversions and enantiomeric excess and is transferable to other β‐chiral amines and amino acids.
Feodor Belov +6 more
wiley +1 more source
Neurobiology of Disease, 2005 Cisplatin causes apoptosis of dorsal root ganglia (DRG) neurons. The amount of platinum binding to DNA correlates with cisplatin toxicity in cancer cells11 Genomic DNA platinum content of cultured embryonic DRG neurons and PC12 cells was assayed using ...
Elizabeth S. McDonald +3 more
doaj
DNA Adduct Detection after Post-Labeling Technique with PCR Amplification (DNA-ADAPT-qPCR) Identifies the Pre-ribosomal RNA Gene as a Direct Target of Platinum-Acridine Anticancer Agents. [PDF]
Chemistry, 2021 Yao X, Bierbach U.
europepmc +1 more source
Methods for Controlling Small GTPase Activity
ChemBioChem, EarlyView.This concept highlights recent and emerging methods for controlling small GTPase activity, encompassing both small‐molecule‐based approaches and protein engineering strategies. The use of these approaches to advance the understanding of small GTPase function, current limitations, and future outlook is discussed.
Benjamin Faulkner +3 more
wiley +1 more source
Cell ReportsSummary: The bypass of DNA lesions by translesion synthesis (TLS) polymerases is a critical step for DNA damage tolerance, allowing the completion of DNA synthesis.
Ashna Dhoonmoon +7 more
doaj
Improved immunocytochemical staining of carcinogen-DNA adducts by a capillary slot block system. [PDF]
, 1990 E. Scherer, Jan van Benthem
openalex +1 more source