Results 181 to 190 of about 2,144,108 (379)

Exploiting SpyTag/SpyCatcher Technology to Design New Artificial Catalytic Copper Proteins

ChemBioChem, EarlyView.
Designing artificial metal sites in proteins is challenging due to the need to place the metal site in precise positions and to tailor the coordination environment of the metal. A modular approach based on the SpyTag/SpyCatcher technology is used to provide the Spy construct with a Cu2+/ATCUN site.
Silvia Gentili, Francesca Miglioli, Valentina Borghesani, Gloria Spagnoli, Denise Bellotti, Davide Cavazzini, Remo Guerrini, Maurizio Remelli, Giovanni Maestri, Simone Ottonello, Angelo Bolchi, Matteo Tegoni   +11 more
wiley   +1 more source

Risk of Breast Cancer Associated with Estrogen DNA Adduct Biomarker. [PDF]

Cancer Epidemiol Biomarkers Prev, 2020
Reding KW, Han CJ, Whittington D, Zahid M, Rogan EG, Langford D, Rohan TE, Chlebowski RT, Cheng TD, Barrington WE, Tinker LF.   +10 more
europepmc   +1 more source

DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality. [PDF]

, 1993
Judy L. Mumford, Xueming Lee, Joellen Lewtas, Tie Lan Young, Regina M. Santella   +4 more
openalex   +1 more source

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

ChemBioChem, EarlyView.
Previous studies reveal an unexpected tendency for amyloid aggregation in specific regions of the C‐terminal domain (CTD) of nucleophosmin 1 (NPM1), a nucleolar chaperone involved in acute myeloid leukemia (AML). Herein, several peptide analogs of NPM1264‐277 (amyloid core) with conservative substitutions are designed and evaluated through biophysical ...
Daniele Florio, Sara La Manna, Giada Raffaella Fiore, Valentina Roviello, Giuliano Castellano, Sossio Fabio Graziano, Anna Maria Malfitano, Daniela Marasco   +7 more
wiley   +1 more source

Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitro.

, 1977
Kenneth Straub, Thomas Meehan, Alma L. Burlingame, M. Calvin   +3 more
openalex   +1 more source

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

ChemBioChem, EarlyView.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source

Sterigmatocystin-DNA interactions: identification of a major adduct formed after metabolic activation in vitro.

, 1979
John M. Essigmann, Lucy Barker, Kerry W. Fowler, M. A. Francisco, V N Reinhold, Gerald N. Wogan   +5 more
openalex   +1 more source

A 32P-postlabeling method for detecting unstable N-7-substituted deoxyguanosine adducts in DNA. [PDF]

, 1994
Dong Yu, Tian-qi Niu, Paula Austin-Ritchie, David B. Ludlum   +3 more
openalex   +1 more source

Linear dose-response relationship for DNA adducts in rat liver from chronic exposure to aflatoxin B1 [PDF]

, 2017
Male F-344 rats were given [3H]aflatoxin B1 (AFB 1) in the drinking water at three exposure levels (0.02, 0.6, 20 μg/l, resulting in average dose levels of 2.2, 73, 2110 ng/kg per day).
Buss, P., Caviezel, M., Lutz, W.K.
core  

Synthesis and Evaluation of Trehalose‐Based Mertansine Warheads for BCG Delivery of Anti‐Cancer Agents

ChemBioChem, Accepted Article.
Non‐muscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette‐Guérin (BCG) immunotherapy as the gold standard for high‐risk patients. BCG elicits a robust immune response but is limited by adverse effects and resistance. To enhance its efficacy, we developed a trehalose‐based conjugation strategy, tethering
Michael Grimmeisen, Xuan Wang, Melissa Weldle, Kerstin Sartory, Sara Benkhelifa, Yu Zhang, Trinh Dao, Jonas Meyer, Oliver Gorka, Olaf Groß, Claudia Jessen-Trefzer   +10 more
wiley   +1 more source