Results 181 to 190 of about 33,588 (237)

Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Weekly moderate‐to‐vigorous activity (≈6 h) induced a marked increase in ACE promoter methylation in exercised knee‐extensor muscle. In combination with the ACE I/D genotype, ACE methylation contributed to ACE gene activity regulation in ways aligning with the slow‐twitch, aerobic muscle phenotype and its metabolic response to endurance exercise ...
Flück Martin, Benedikt Gasser, Giraud Marie‐Noëlle   +2 more
wiley   +1 more source

Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer. [PDF]

J Biol Chem, 2017
Minko IG, Rizzo CJ, Lloyd RS.
europepmc   +1 more source

DFTB Parametrization at the Example of Platinum—Implementation, Validation and Practical Considerations

Journal of Computational Chemistry, Volume 47, Issue 7, March 15, 2026.
Development and comprehensive validation of 3ob‐compatible DFTB3 parameters for platinum, enabling efficient and reliable simulations of a wide range of Pt‐containing systems. ABSTRACT Practical considerations for the parametrization of the transition metal platinum within the third‐order density‐functional tight‐binding (DFTB3) method are presented ...
Felix R. S. Purtscher, Armin Penz, Josef M. Gallmetzer, Jakob Gamper, Thomas S. Hofer   +4 more
wiley   +1 more source

Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome. [PDF]

Chem Res Toxicol, 2015
Wauchope OR, Beavers WN, Galligan JJ, Mitchener MM, Kingsley PJ, Marnett LJ.   +5 more
europepmc   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Photochemical Aerobic Upcycling of Polystyrene Plastics via Indium Salt‐Mediated Synergistic Catalysis

ChemSusChem, Volume 19, Issue 5, 13 March 2026.
This study presents a practical aerobic photochemical strategy for the upcycling of polystyrene waste, combining bromine radical mediation with InBr3 catalysis. The approach efficiently depolymerizes diverse PS materials under mild conditions, yielding benzoic acid and enabling downstream production of value‐added compounds. The photochemical upcycling
Lydia Lavrenti, Christos Papagkikas, Olga G. Mountanea, Christoforos G. Kokotos   +3 more
wiley   +1 more source

Cancer‐associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi‐omics and machine learning analysis

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer‐associated fibroblasts (aCAFs) on survival outcomes and immune responses and examined their association with various ...
Myungsun Shim, One‐Zoong Kim, Byoung Kwan Son, Jung Ki Jo, Seung Wook Lee, Hong Sang Moon, Hyung Suk Kim, Mi Jung Kwon, Sung Hak Lee, Yung‐Kyun Noh, Kyueng‐Whan Min   +10 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, Volume 16, Issue 3, Page 584-594, March 2026.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Continuous‐Flow Photocatalytic Degradation of Glyphosate and Aminomethylphosphonic Acid Under Simulated Sunlight with TiO2‐Coated Poly(vinylidene fluoride) Membrane

Advanced Functional Materials, Volume 36, Issue 21, 12 March 2026.
Glyphosate (GLY) and its primary metabolite, aminomethylphosphonic acid (AMPA), are photodegraded using a poly(vinylidene fluoride) membrane with immobilized titanium dioxide (PVDF‐TiO2) in a continuous flow‐through operation under solar light. At optimized conditions, the PVDF‐TiO2 membrane achieved 95% GLY and 80% AMPA removal with •O2− as the ...
Phuong B. Trinh, Siqi Liu, Nurul F. Himma, Béla Fiser, Andrea I. Schäfer   +4 more
wiley   +1 more source

Organic and Metallacages for Chemical Sensing: Progress in Water‐Compatible Systems

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
Supramolecular cages function as three‐dimensional receptors for selective molecular recognition and sensing, and this review outlines design principles for water‐stable architectures, key analyte‐ and medium‐dependent challenges, recent water‐compatible examples (including polymer‐integrated systems), and future opportunities for cage‐based ...
Rabia Zahid, Martina Viola, Maria Vittoria Balli, Guillermo Moreno‐Alcántar, Pierre Picchetti   +4 more
wiley   +1 more source