Results 11 to 20 of about 40,057 (283)

Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary DNA Adducts and Cytochrome P450 (CYP)1B1 by Dietary Antioxidants, Omega-3 Fatty Acids, in Mice

Antioxidants, 2022
Numerous human and animal studies have reported positive correlation between carcinogen-DNA adduct levels and cancer occurrence. Therefore, attenuation of DNA adduct levels would be expected to suppress tumorigenesis.
Guodong Zhou, Weiwu Jiang, Guobin Xia, Lihua Wang, Molly Richardson, Chun Chu, Bhagavatula Moorthy   +6 more
doaj   +1 more source

Flipping Back of Extrahelical Guanine after Methyl Repair

Bibechana, 2022
Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Rajendra Prasad Koirala, Narayan Prasad Adhikari   +1 more
doaj   +3 more sources

Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde

Scientific Reports, 2023
To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde.
Zhijun Zhang, Yuan Yang, Changjun Hu, Zaiqi Zhang   +3 more
doaj   +1 more source

Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study

Bibechana, 2022
Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Bibek Subedi, Narayan Adhikari
doaj   +3 more sources

Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer. [PDF]

PLoS ONE, 2016
We report herein the development, functional and molecular characterization of an isogenic, paired bladder cancer cell culture model system for studying platinum drug resistance.
Sisi Wang, Hongyong Zhang, Tiffany M Scharadin, Maike Zimmermann, Bin Hu, Amy Wang Pan, Ruth Vinall, Tzu-yin Lin, George Cimino, Patrick Chain, Momchilo Vuyisich, Cheryl Gleasner, Kim Mcmurry, Michael Malfatti, Kenneth Turteltaub, Ralph de Vere White, Chong-xian Pan, Paul T Henderson   +17 more
doaj   +1 more source

Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Química Nova, 2010
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA.
Maria Lara P. M. Arguelho, José do Patrocínio H. Alves, Nelson R. Stradiotto, Valdemar Lacerda Júnior, José Maria Pires, Adilson Beatriz   +5 more
doaj   +1 more source

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells. [PDF]

PLoS ONE, 2013
PURPOSE:The combination of systemic cisplatin with local and regional radiotherapy as primary treatment of head and neck squamous cell carcinoma (HNSCC) leads to cure in approximately half of the patients.
Sanne R Martens-de Kemp, Simone U Dalm, Fiona M J Wijnolts, Arjen Brink, Richard J Honeywell, Godefridus J Peters, Boudewijn J M Braakhuis, Ruud H Brakenhoff   +7 more
doaj   +1 more source

Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems

Toxicology Reports, 2023
Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed.
Sarah Ceylan Krassnig, Marina Mäser, Nicola Anna Probst, Jens Werner, Charlotte Schlett, Nina Schumann, Gudrun von Scheven, Aswin Mangerich, Alexander Bürkle   +8 more
doaj   +1 more source

Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates. [PDF]

PLoS ONE, 2011
The ATR-Chk1 DNA damage checkpoint pathway is a critical regulator of the cellular response to DNA damage and replication stress in human cells.
Seçil Yilmaz, Aziz Sancar, Michael G Kemp   +2 more
doaj   +1 more source

Biomarker-based evaluation of aflatoxin B1 exposure in cattle [PDF]

Veterinary World
Background and Aim: Assessment of aflatoxin B1 (AFB1) exposure in cattle traditionally relies on feed analysis, which may not reflect chronic exposure or accurately indicate individual susceptibility.
Priyadharshini Ponnusamy, Umaya Suganthi Rajendran, Madhavan Gopalakrishnan Nair, Uma Sambath, Raja Kumar, Jacob Thanislass, Avinash Warundeo Lakkawar, Vijayalakshmi Padmanaban, Poobitha Subbarayan   +8 more
doaj   +1 more source