Results 11 to 20 of about 33,588 (237)

Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer. [PDF]

PLoS ONE, 2016
We report herein the development, functional and molecular characterization of an isogenic, paired bladder cancer cell culture model system for studying platinum drug resistance.
Sisi Wang, Hongyong Zhang, Tiffany M Scharadin, Maike Zimmermann, Bin Hu, Amy Wang Pan, Ruth Vinall, Tzu-yin Lin, George Cimino, Patrick Chain, Momchilo Vuyisich, Cheryl Gleasner, Kim Mcmurry, Michael Malfatti, Kenneth Turteltaub, Ralph de Vere White, Chong-xian Pan, Paul T Henderson   +17 more
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Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Química Nova, 2010
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA.
Maria Lara P. M. Arguelho, José do Patrocínio H. Alves, Nelson R. Stradiotto, Valdemar Lacerda Júnior, José Maria Pires, Adilson Beatriz   +5 more
doaj   +1 more source

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells. [PDF]

PLoS ONE, 2013
PURPOSE:The combination of systemic cisplatin with local and regional radiotherapy as primary treatment of head and neck squamous cell carcinoma (HNSCC) leads to cure in approximately half of the patients.
Sanne R Martens-de Kemp, Simone U Dalm, Fiona M J Wijnolts, Arjen Brink, Richard J Honeywell, Godefridus J Peters, Boudewijn J M Braakhuis, Ruud H Brakenhoff   +7 more
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Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems

Toxicology Reports, 2023
Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed.
Sarah Ceylan Krassnig, Marina Mäser, Nicola Anna Probst, Jens Werner, Charlotte Schlett, Nina Schumann, Gudrun von Scheven, Aswin Mangerich, Alexander Bürkle   +8 more
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Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates. [PDF]

PLoS ONE, 2011
The ATR-Chk1 DNA damage checkpoint pathway is a critical regulator of the cellular response to DNA damage and replication stress in human cells.
Seçil Yilmaz, Aziz Sancar, Michael G Kemp   +2 more
doaj   +1 more source

Biomarker-based evaluation of aflatoxin B1 exposure in cattle [PDF]

Veterinary World
Background and Aim: Assessment of aflatoxin B1 (AFB1) exposure in cattle traditionally relies on feed analysis, which may not reflect chronic exposure or accurately indicate individual susceptibility.
Priyadharshini Ponnusamy, Umaya Suganthi Rajendran, Madhavan Gopalakrishnan Nair, Uma Sambath, Raja Kumar, Jacob Thanislass, Avinash Warundeo Lakkawar, Vijayalakshmi Padmanaban, Poobitha Subbarayan   +8 more
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Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. [PDF]

PLoS ONE, 2011
Many carcinogenic polycyclic aromatic hydrocarbons (PAHs) and their metabolites can bind covalently to DNA. Carcinogen-DNA adducts may lead to mutations in critical genes, eventually leading to cancer.
Guo-Dong Zhou, Huiping Zhu, Tracie D Phillips, Jianbo Wang, Shi-Zhou Wang, Fen Wang, Brad A Amendt, Xanthi I Couroucli, Kirby C Donnelly, Bhagavatula Moorthy   +9 more
doaj   +1 more source

Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair

Nature Communications, 2021
The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure
Trevor van Eeuwen, Yoonjung Shim, Hee Jong Kim, Tingting Zhao, Shrabani Basu, Benjamin A. Garcia, Craig D. Kaplan, Jung-Hyun Min, Kenji Murakami   +8 more
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Identification of new candidate biomarkers to support doxorubicin treatments in canine cancer patients

BMC Veterinary Research, 2021
Background Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies.
Kristine Walters, Alessia Stornetta, Foster Jacobs, Peter W. Villalta, Maria Razzoli, Marianne Grant, Beshay Zordoky, Alessandro Bartolomucci, Antonella Borgatti, Silvia Balbo   +9 more
doaj   +1 more source

Method Development and Validation for Measuring O6-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry

Drug Design, Development and Therapy, 2021
Yahdiana Harahap,1,2 Aurelia Maria Vianney,1 Herman Suryadi1 1Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia; 2Indonesia Defense University, Bogor, 16810, West Java, IndonesiaCorrespondence: Yahdiana Harahap Email yahdiana@
Harahap Y, Vianney AM, Suryadi H
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