Particle and Fibre Toxicology, 2009 Titanium dioxide (TiO2), also known as titanium (IV) oxide or anatase, is the naturally occurring oxide of titanium. It is also one of the most commercially used form.
Schins Roel PF +5 more
doaj +2 more sources
Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study
Bibechana, 2022 Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Bibek Subedi, Narayan Adhikari
doaj +3 more sources
Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity. [PDF]
Chem Res Toxicol, 2015 This rapid report focuses on the pharmacodynamic mechanism of the carboplatin/paclitaxel combination and correlates it with its cytotoxicity. Consistent with the synergistic to additive antitumor activity (the combination index ranging from 0.53 to 0.94),
Jiang S +7 more
europepmc +2 more sources
Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer. [PDF]
PLoS ONE, 2016 We report herein the development, functional and molecular characterization of an isogenic, paired bladder cancer cell culture model system for studying platinum drug resistance.
Sisi Wang +17 more
doaj +1 more source
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells. [PDF]
PLoS ONE, 2013 PURPOSE:The combination of systemic cisplatin with local and regional radiotherapy as primary treatment of head and neck squamous cell carcinoma (HNSCC) leads to cure in approximately half of the patients.
Sanne R Martens-de Kemp +7 more
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Química Nova, 2010 The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA.
Maria Lara P. M. Arguelho +5 more
doaj +1 more source
Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]
, 2010 Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Baynes +48 more
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Interactions of Cisplatin and Daunorubicin at the chromatin level [PDF]
, 2020 Unexpectedly, the widely used anticancer agents Cisplatin (Cis-Pt) and Daunorubicin (Dauno) exhibited cell type- and concentration-dependent synergy or antagonism in vitro.
Bacsó, Zsolt +7 more
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Carcinogenic adducts induce distinct DNA polymerase binding orientations [PDF]
, 2013 DNA polymerases must accurately replicate DNA to maintain genome integrity. Carcinogenic adducts, such as 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF), covalently bind DNA bases and promote mutagenesis near the adduct site.
Markiewicz, RP +3 more
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DNA adducts in fish following an oil spill exposure [PDF]
, 2006 On 12 December 1999, one third of the load of the Erika tanker, amounting to about 10,000 t crude oil flowed into sea waters close to the French Atlantic Coast.
A. Amat +36 more
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