Results 201 to 210 of about 33,588 (237)
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DNA adducts of halogenated hydrocarbons
Journal of Cancer Research and Clinical Oncology, 1986Although formation of DNA adducts has been postulated for several halomethanes, no chemical identification of such adducts has been performed so far. There is, however, evidence that methyl chloride does not act biologically as a DNA methylating agent. 1,2-Dichloroethane and 1,2-dibromoethane are activated through conjugation with glutathione. There is
H M, Bolt +3 more
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DNA Adduct-Directed Synthetic Nucleosides
Accounts of Chemical Research, 2019Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O6-alkylguanine ( O6-alkylG) DNA adducts are strongly miscoding during DNA replication when the damaged nucleobase is a template for polymerase-mediated translesion DNA synthesis.
Michael H. Räz +3 more
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DNA adducts in bronchial biopsies
International Journal of Cancer, 1991AbstractTo investigate the feasibility of measuring DNA‐carcinogen adducts in the lungs of non‐surgical patients, endobronchial biopsies were obtained from 78 patients undergoing routine diagnostic bronchoscopy. Lung cancer was present in 37 (47%) of the patients.
B P, Dunn +6 more
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DNA adducts from chemotherapeutic agents
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1996The guiding principle of early work was the hypothesis that the anti-cancer alkylating drugs acted through their ability to cross-link macromolecules essential for cell division. Not long afterwards, DNA was specified as the essential target, and support for the hypothesis came from evidence that the archetypal agent, mustard gas, could link guanine ...
P D, Lawley, D H, Phillips
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Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999The quantitative relationship between DNA adducts and tumor incidence is evaluated in this review. All available data on DNA adduct levels determined after repeated administration of a carcinogen to rats or mice have been compiled. The list comprised 27 chemicals, of all major structural classes of carcinogens. For the correlation with tumor incidence,
M, Otteneder, W K, Lutz
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DNA Adducts: Endogenous and Induced
Toxicologic Pathology, 2000Human exposure to DNA damaging agents can arise from exogenous sources or endogenous processes that occur normally or in pathological states. DNA isolated from human tissues, obtained from the very young to the old, contains detectable amounts of a number of different types of DNA adducts that reflect exposure to both known carcinogens and as yet ...
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2006
DNA adducts reflect the amount of a ▶ xenobiotic that covalently reacts with nucleic acid bases at the target site (biologically effective dose) or in surrogate tissues (▶Surrogate markers). DNA adducts are mechanistically more relevant to ▶ carcinogenesis than the internal dose of a carcinogen, since they take into account interindividual differences ...
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DNA adducts reflect the amount of a ▶ xenobiotic that covalently reacts with nucleic acid bases at the target site (biologically effective dose) or in surrogate tissues (▶Surrogate markers). DNA adducts are mechanistically more relevant to ▶ carcinogenesis than the internal dose of a carcinogen, since they take into account interindividual differences ...
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Journal of Cancer Research and Clinical Oncology, 1986
Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-
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Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-
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Nucleosides and Nucleotides, 1991
Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Pekka Sillanaukee +2 more
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Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Pekka Sillanaukee +2 more
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Studies of chlorambucil—DNA adducts
Biochemical Pharmacology, 1992Chlorambucil (CLB) is a bifunctional nitrogen mustard whose therapeutic and major side-effects are thought to be caused by binding to DNA. HPLC analysis of hydrolyzed DNA from L1210 cells incubated with [14C]CLB generated two peaks of radioactivity, indicating the formation of two or more major adducts.
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