Results 211 to 220 of about 33,588 (237)
Some of the next articles are maybe not open access.
DNA adduct assay in cervical epithelium
Diagnostic Cytopathology, 1994AbstractNumerous epidemiological studies have shown that there is an association between smoking and cervical cancer. However, the essential evidence to show whether this relationship is casual or causal is lacking. The demonstration of DNA modification by tobacco components in the cervical epithelium would provide biochemical evidence to support a ...
A M, Simons, D H, Phillips, D V, Coleman
openaire +2 more sources
Specificity of platinum–DNA adduct repair
Journal of Inorganic Biochemistry, 1999Cell lines with resistance to cisplatin and carboplatin often retain sensitivity to platinum complexes with different carrier ligands (e.g., oxaliplatin and JM216). HeLa cell extracts were shown to excise cisplatin, oxaliplatin, and JM216 adducts with equal efficiency, suggesting that nucleotide excision repair does not contribute to the carrier-ligand
S G, Chaney, A, Vaisman
openaire +2 more sources
DNA adducts and human atherosclerotic lesions
International Journal of Hygiene and Environmental Health, 2001It has been hypothesized that mutational events may be involved in the atherogenetic process and that at least a portion of atherosclerotic plaques may be the results of monoclonal proliferation of a single mutated smooth muscle cell (SMC). Therefore, atherosclerosis may be similar to carcinogenesis and may have an environmental etiology.
B, Binková +5 more
openaire +2 more sources
DNA Adducts in Cancer Chemotherapy
Journal of Medicinal ChemistryDNA adducting drugs, including alkylating agents and platinum-containing drugs, are prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction with DNA, resulting in the formation of DNA addition products known as DNA adducts. While these adducts are well-accepted to induce cancer cell death, understanding of their specific
openaire +2 more sources
2010
Increased production of reactive oxygen species during oxidative stress can initiate the formation of lipid hydroperoxides, which undergo homolytic decomposition to the α, β-unsaturated aldehydic bifunctional electrophiles, 4-oxo-2(E)-nonenal (ONE), 4-hydroxy-2(E)-nonenal (HNE), 4-hydroperoxy-2(E)-nonenal (HPNE), and malondialdehyde (MDA).
Seon Hwa Lee, Ian A. Blair
openaire +1 more source
Increased production of reactive oxygen species during oxidative stress can initiate the formation of lipid hydroperoxides, which undergo homolytic decomposition to the α, β-unsaturated aldehydic bifunctional electrophiles, 4-oxo-2(E)-nonenal (ONE), 4-hydroxy-2(E)-nonenal (HNE), 4-hydroperoxy-2(E)-nonenal (HPNE), and malondialdehyde (MDA).
Seon Hwa Lee, Ian A. Blair
openaire +1 more source
DNA Adducts and Carcinogenesis
1989A central tenet of cancer research is that tumors arise from cells that have undergone a permanent heritable change in their genetic material. This hypothesis originated from the observation that tumor cells have lost normal growth-control mechanisms and transmit this characteristic to their progeny. It is supported by the findings that most chemically
Frederick A. Beland, Miriam C. Poirier
openaire +1 more source
Endogenous Production of DNA Adducts
Regulatory Toxicology and Pharmacology, 1996R G, Nath +3 more
openaire +2 more sources
‘Mediterranean diet’ and DNA adducts
European Journal of Cancer Prevention, 2000M, Peluso, P, Vineis
openaire +2 more sources