Results 251 to 260 of about 40,057 (283)

Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999
The quantitative relationship between DNA adducts and tumor incidence is evaluated in this review. All available data on DNA adduct levels determined after repeated administration of a carcinogen to rats or mice have been compiled. The list comprised 27 chemicals, of all major structural classes of carcinogens. For the correlation with tumor incidence,
M, Otteneder, W K, Lutz
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DNA Adducts: Endogenous and Induced

Toxicologic Pathology, 2000
Human exposure to DNA damaging agents can arise from exogenous sources or endogenous processes that occur normally or in pathological states. DNA isolated from human tissues, obtained from the very young to the old, contains detectable amounts of a number of different types of DNA adducts that reflect exposure to both known carcinogens and as yet ...
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Adducts to DNA

2006
DNA adducts reflect the amount of a ▶ xenobiotic that covalently reacts with nucleic acid bases at the target site (biologically effective dose) or in surrogate tissues (▶Surrogate markers). DNA adducts are mechanistically more relevant to ▶ carcinogenesis than the internal dose of a carcinogen, since they take into account interindividual differences ...
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DNA adducts and cell cycle

Journal of Cancer Research and Clinical Oncology, 1986
Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-
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Acetaldehyde Adducts of DNA

Nucleosides and Nucleotides, 1991
Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Pekka Sillanaukee, Leena M. Vilpo, Juhani A. Vilpo   +2 more
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Studies of chlorambucil—DNA adducts

Biochemical Pharmacology, 1992
Chlorambucil (CLB) is a bifunctional nitrogen mustard whose therapeutic and major side-effects are thought to be caused by binding to DNA. HPLC analysis of hydrolyzed DNA from L1210 cells incubated with [14C]CLB generated two peaks of radioactivity, indicating the formation of two or more major adducts.
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DNA adduct assay in cervical epithelium

Diagnostic Cytopathology, 1994
AbstractNumerous epidemiological studies have shown that there is an association between smoking and cervical cancer. However, the essential evidence to show whether this relationship is casual or causal is lacking. The demonstration of DNA modification by tobacco components in the cervical epithelium would provide biochemical evidence to support a ...
A M, Simons, D H, Phillips, D V, Coleman
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Specificity of platinum–DNA adduct repair

Journal of Inorganic Biochemistry, 1999
Cell lines with resistance to cisplatin and carboplatin often retain sensitivity to platinum complexes with different carrier ligands (e.g., oxaliplatin and JM216). HeLa cell extracts were shown to excise cisplatin, oxaliplatin, and JM216 adducts with equal efficiency, suggesting that nucleotide excision repair does not contribute to the carrier-ligand
S G, Chaney, A, Vaisman
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DNA adducts and human atherosclerotic lesions

International Journal of Hygiene and Environmental Health, 2001
It has been hypothesized that mutational events may be involved in the atherogenetic process and that at least a portion of atherosclerotic plaques may be the results of monoclonal proliferation of a single mutated smooth muscle cell (SMC). Therefore, atherosclerosis may be similar to carcinogenesis and may have an environmental etiology.
B, Binková, P, Strejc, O, Boubelík, Z, Stávková, I, Chvátalová, R J, Srám   +5 more
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DNA Adducts in Cancer Chemotherapy

Journal of Medicinal Chemistry
DNA adducting drugs, including alkylating agents and platinum-containing drugs, are prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction with DNA, resulting in the formation of DNA addition products known as DNA adducts. While these adducts are well-accepted to induce cancer cell death, understanding of their specific
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