Results 21 to 30 of about 40,057 (283)
Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. [PDF]
PLoS ONE, 2011 Many carcinogenic polycyclic aromatic hydrocarbons (PAHs) and their metabolites can bind covalently to DNA. Carcinogen-DNA adducts may lead to mutations in critical genes, eventually leading to cancer.
Guo-Dong Zhou +9 more
doaj +1 more source
Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
Nature Communications, 2021 The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure
Trevor van Eeuwen +8 more
doaj +1 more source
Drug Design, Development and Therapy, 2021 Yahdiana Harahap,1,2 Aurelia Maria Vianney,1 Herman Suryadi1 1Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia; 2Indonesia Defense University, Bogor, 16810, West Java, IndonesiaCorrespondence: Yahdiana Harahap Email yahdiana@
Harahap Y, Vianney AM, Suryadi H
doaj
BMC Veterinary Research, 2021 Background Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies.
Kristine Walters +9 more
doaj +1 more source
Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. [PDF]
PLoS ONE, 2010 BACKGROUND: Nucleotide excision repair (NER) and base excision repair (BER) are the primary mechanisms for repair of bulky adducts caused by chemical agents, such as PAHs.
Guixiang Ji +8 more
doaj +1 more source
Genes and Environment, 2021 Background A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings.
Ippei Ohnishi +15 more
doaj +1 more source
Sperm DNA oxidative damage and DNA adducts [PDF]
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015 The objective of this study was to investigate DNA damage and adducts in sperm from coke oven workers who have been exposed to polycyclic aromatic hydrocarbons. A longitudinal study was conducted with repeated measurements during spermatogenesis. Coke-oven workers (n=112) from a coke-oven plant served the PAH-exposed group, while administrators and ...
Jeng, Hueiwang Anna +3 more
openaire +3 more sources
Pembentukan 8-OHdG Dari Zat Toksik Pemicu Radikal Bebas
Pharmaceutical Sciences and Research, 2015 This study was conducted to observe the profile of DNA Adduct (8-OHdG) formation as DNA damage indicators, by using calf thymus DNA incubated with toxic and carcinogenic compounds. The compounds which could trigger free radicals in this research were PAH(
Intan Cahaya Dani, Budiawan
doaj +1 more source
DNA Damage and the Gut Microbiome: From Mechanisms to Disease Outcomes
DNA, 2023 Both the number of cells and the collective genome of the gut microbiota outnumber their mammalian hosts, and the metabolic and physiological interactions of the gut microbiota with the host have not yet been fully characterized.
Yun-Chung Hsiao +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source