Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation [PDF]
, 1997 Reductive activation of racemic 1,10-bis(acetoxy)-7-methoxymitosene WV15 in the presence of DNA, followed by enzymatic digestion and HPLC analysis, revealed the formation of various DNA adducts.
Duynhoven, John P.M. van +8 more
core +2 more sources
Analytical Chemistry, 2016 Epidemiologic studies have reported an association between frequent consumption of well-done cooked meats and prostate cancer risk. However, unambiguous physiochemical markers of DNA damage from carcinogens derived from cooked meats, such as DNA adducts,
S. Xiao +8 more
semanticscholar +1 more source
Diet-related DNA adduct formation in relation to carcinogenesis.
Nutrition reviews, 2016 The human diet contributes significantly to the initiation and promotion of carcinogenesis. It has become clear that the human diet contains several groups of natural foodborne chemicals that are at least in part responsible for the genotoxic, mutagenic,
L. Hemeryck, L. Vanhaecke
semanticscholar +1 more source
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates. [PDF]
PLoS ONE, 2011 The ATR-Chk1 DNA damage checkpoint pathway is a critical regulator of the cellular response to DNA damage and replication stress in human cells.
Seçil Yilmaz +2 more
doaj +1 more source
Insights into DNA platination within unusual structural settings [PDF]
, 2011 2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor reaction and product formation between [Pt(15NH3)2I2] and nucleic acids possessing irregular topologies and containing site specific phosphorothioate substitution in the phosphodiester backbone.
Harvie, Stephanie +2 more
core +2 more sources
Mutational properties of the primary aflatoxin B1-DNA adduct. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1996 The mutagenic activity of the major DNA adduct formed by the liver carcinogen aflatoxin B1 (AFB1) was investigated in vivo. An oligonucleotide containing a single 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) adduct was inserted into the ...
Eric Bailey +4 more
openalex +2 more sources
Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. [PDF]
PLoS ONE, 2011 Many carcinogenic polycyclic aromatic hydrocarbons (PAHs) and their metabolites can bind covalently to DNA. Carcinogen-DNA adducts may lead to mutations in critical genes, eventually leading to cancer.
Guo-Dong Zhou +9 more
doaj +1 more source
An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]
, 2016 Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan +16 more
core +2 more sources
Error-prone Replication Bypass of the Primary Aflatoxin B1 DNA Adduct, AFB1-N7-Gua*
Journal of Biological Chemistry, 2014 Background: Aflatoxin B1 exposure causes mutations that are associated with liver cancer. Results: The AFB1-N7-Gua adduct is highly mutagenic in primate cells, with contributions by both replicative and translesion synthesis DNA polymerases.
Ying-Chih Lin +5 more
semanticscholar +1 more source
Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran [PDF]
, 2009 We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world.
Biramijamal, F. +4 more
core +3 more sources