Results 301 to 310 of about 2,144,108 (379)

Shining Bright at 960 nm: A 28‐Silver‐Atom Nanorod Stabilized by DNA

Small Structures, EarlyView.
Single‐crystal X‐ray data reveal the structure of a 28‐silver‐atom cluster wrapped within two DNA oligomers. In the crystalline state, two chlorido ligands are detected, which are absent in the mass spectrometry data of the solution state. With 12 valence electrons, the silver cluster has an absorption band situated at 835 nm and an emission peaking at
Giacomo Romolini, Hiroki Kanazawa, Christian Brinch Mollerup, Mikkel Baldtzer Liisberg, Simon Wentzel Lind, Zhiyu Huang, Cecilia Cerretani, Jiro Kondo, Tom Vosch   +8 more
wiley   +1 more source

DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A. [PDF]

Chem Res Toxicol, 2017
Stornetta A, Villalta PW, Gossner F, Wilson WR, Balbo S, Sturla SJ.   +5 more
europepmc   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Leptin influences estrogen metabolism and increases DNA adduct formation in breast cancer cells. [PDF]

Cancer Biol Med, 2016
Shouman S, Wagih M, Kamel M.
europepmc   +1 more source

DNA Adducts as Exposure Biomarkers and Indicators of Cancer Risk

, 1997
Miriam C. Poirier
openalex   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

British Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding, Chengqing Ning, Shao‐Ru Chen, Hao‐Ran Yin, Jing Xu, Ying Wang   +5 more
wiley   +1 more source

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone. [PDF]

Arch Toxicol, 2017
Arlt VM, Meinl W, Florian S, Nagy E, Barta F, Thomann M, Mrizova I, Krais AM, Liu M, Richards M, Mirza A, Kopka K, Phillips DH, Glatt H, Stiborova M, Schmeiser HH.   +15 more
europepmc   +1 more source

Circumventing glioblastoma resistance to temozolomide through optimal drug combinations designed by systems pharmacology and machine learning

British Journal of Pharmacology, EarlyView.
Background and Purpose Glioblastoma (GBM), the most frequent and aggressive brain tumour in adults, is associated with a dismal prognostic despite intensive treatment involving surgery, radiotherapy and temozolomide (TMZ)‐based chemotherapy. The initial or acquired resistance of GBM to TMZ appeals for precision medicine approaches to the design of ...
Sergio Corridore, Maïté Verreault, Hugo Martin, Thibault Delobel, Cécile Carrère, Ahmed Idbaih, Annabelle Ballesta   +6 more
wiley   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin, Cristina Lagatolla, Sofia Sindici Forgiarini, Mathias Haag, Sylvia Karin Neef, Manola Comar, Elke Schaeffeler, Barbara Bellich, Matteo Bramuzzo, Giuliana Decorti, Marianna Lucafò, Ute Hofmann, Matthias Schwab, Gabriele Stocco   +13 more
wiley   +1 more source

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

The FEBS Journal, EarlyView.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser, Milena Lubisch, Emma Schröder, Luka Ressmann, Marie Nicolaus, Dustin Leusder, Sven Moyzio, Robert Peuss, Antonio Miranda‐Vizuete, Eva Liebau   +9 more
wiley   +1 more source