Results 311 to 320 of about 2,144,108 (379)

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara, Eda Dogan, Vildan Bozok, Cagdas Aktan, Ece Cakiroglu, Zuhal Eroglu, Duygu Aygunes Jafari, Kemal Sami Korkmaz, Serif Senturk, Buket Kosova   +9 more
wiley   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

HR-MS Analysis of the Covalent Binding of Edaravone to 5-Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5-Formylcytidine Residue. [PDF]

Rapid Commun Mass Spectrom
Regnault R, Kouach M, Goossens L, Thuru X, Bailly C, Goossens JF.   +5 more
europepmc   +1 more source

Metabolomic Profiles of Oral Rinse Samples to Distinguish Severe Periodontitis Patients From Non‐Periodontitis Controls

Journal of Periodontal Research, EarlyView.
Metabolomic fingerprints analyzed from oral rinses are able to distinguish between severe periodontitis (stage III/IV) patients and non‐periodontitis controls. ABSTRACT Aims To explore the potential of metabolomic profiles of oral rinse samples to distinguish between patients with severe periodontitis (stage III/IV) and non‐periodontitis controls. This
Madeline X. F. Kosho, Alessio Ciurli, Martin Giera, Jacques Neefjes, Bruno G. Loos   +4 more
wiley   +1 more source

Genomic stress in diseases stemming from defects in the second brain

Neurogastroenterology &Motility, EarlyView.
The enteric nervous system, a.k.a., second brain, is subject to a range of genotoxic exposures that include intrinsic oxidative stress and extrinsic agents associated with ingested foods, inflammation, and dysbiosis. Resulting DNA damage, if left unrepaired, can induce cell dysfunction or death, resulting in gut abnormalities and enteric neuropathy ...
Lobke Marie M. Mombeek, Werend Boesmans, David M. Wilson III   +2 more
wiley   +1 more source

DNA adducts form in mouse lung and liver after oral naphthalene exposure. [PDF]

Toxicol Sci
Domanico MC, Collette NM, Ubick E, Ding X, Buchholz BA, Van Winkle LS.   +5 more
europepmc   +1 more source

Resolving floral development dynamics using genome and single‐cell temporal transcriptome of Dendrobium devonianum

Plant Biotechnology Journal, EarlyView.
Summary Dendrobium devonianum, a species of the Orchidaceae family, is notable for its unique floral characteristics, which include two yellow spots and purple tips on its labellum, as well as fringed edges. However, the molecular mechanisms underlying flower pattern formation in D.
Jing Wang, Ying Zhou, Manchang Zhang, Xinping Li, Tingxia Liu, Yinglin Liu, He Xie, Kaiying Wang, Peng Li, Zhichao Xu, Baozhong Duan   +10 more
wiley   +1 more source

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, EarlyView.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

Use of updated mortality study of ethylene oxide manufacturing workers to inform cancer risk assessment

Risk Analysis, EarlyView.
Abstract The two most recent cancer risk assessments for ethylene oxide (EO) are based on the same epidemiologic study of sterilant workers conducted by the National Institute of Occupational Safety and Health (NIOSH) but result in cancer risk estimates with three orders of magnitude difference, despite relying on the same assumption of a default ...
Ciriaco Valdez‐Flores, Abby A. Li, Thomas J. Bender, M. Jane Teta   +3 more
wiley   +1 more source

Cytotoxicity and Binding to DNA, Lysozyme, Ribonuclease A, and Human Serum Albumin of the Diiodido Analog of Picoplatin. [PDF]

Inorg Chem
Ferraro G, Pracharova J, Gotte G, Massai L, Berecka M, Starha P, Messori L, Merlino A.   +7 more
europepmc   +1 more source