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DNA adducts of halogenated hydrocarbons [PDF]
Journal of Cancer Research and Clinical Oncology, 1986 Although formation of DNA adducts has been postulated for several halomethanes, no chemical identification of such adducts has been performed so far. There is, however, evidence that methyl chloride does not act biologically as a DNA methylating agent. 1,2-Dichloroethane and 1,2-dibromoethane are activated through conjugation with glutathione. There is
R. J. Laib +3 more
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Medical Hypotheses, 2019
DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
Basant K. Puri, Jean A. Monro, C. Ijeh
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DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
Basant K. Puri, Jean A. Monro, C. Ijeh
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Toxicology, 1995
Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
Aage Haugen +2 more
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Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
Aage Haugen +2 more
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Journal of the American Chemical Society, 2015
The ability to detect DNA modification sites at single base resolution could significantly advance studies regarding DNA adduct levels, which are extremely difficult to determine.
Laura A. Wyss +6 more
semanticscholar +1 more source
The ability to detect DNA modification sites at single base resolution could significantly advance studies regarding DNA adduct levels, which are extremely difficult to determine.
Laura A. Wyss +6 more
semanticscholar +1 more source
, 2006 DNA adducts reflect the amount of a ▶ xenobiotic that covalently reacts with nucleic acid bases at the target site (biologically effective dose) or in surrogate tissues (▶Surrogate markers). DNA adducts are mechanistically more relevant to ▶ carcinogenesis than the internal dose of a carcinogen, since they take into account interindividual differences ...
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Nucleosides and Nucleotides, 1991
Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Juhani Vilpo +2 more
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Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Juhani Vilpo +2 more
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Chemical Research in Toxicology, 2012
Acrylamide (AA) is formed during the heating of food and is classified as a genotoxic carcinogen. The margin of exposure (MOE), representing the distance between the bench mark dose associated with 10% tumor incidence in rats and the estimated average ...
N. Watzek +12 more
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Acrylamide (AA) is formed during the heating of food and is classified as a genotoxic carcinogen. The margin of exposure (MOE), representing the distance between the bench mark dose associated with 10% tumor incidence in rats and the estimated average ...
N. Watzek +12 more
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Identification of DNA Adducts of Methylglyoxal
Chemical Research in Toxicology, 2005Methylglyoxal (MG) is a sugar degradation product, which is endogenously formed by fragmentation of triose phosphates during glycolysis, ketone body metabolism of acetone, and catabolism of threonine. Food, beverages, and medical products are important exogenous sources with concentrations of up to 100 microM MG.
Matthias Frischmann +3 more
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DNA adducts in bronchial biopsies
International Journal of Cancer, 1991AbstractTo investigate the feasibility of measuring DNA‐carcinogen adducts in the lungs of non‐surgical patients, endobronchial biopsies were obtained from 78 patients undergoing routine diagnostic bronchoscopy. Lung cancer was present in 37 (47%) of the patients.
Wan-Fung Kwan +6 more
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Environmental Science and Technology, 2011
This study investigated the formation of DNA adducts of polybrominated diphenyl ethers (PBDEs) and the possible mechanisms. DNA adduction was conducted by in vitro reaction of deoxyguanosine (dG) and DNA with PBDE-quinone (PBDE-Q) metabolites, and DNA ...
Yongquan Lai +4 more
semanticscholar +1 more source
This study investigated the formation of DNA adducts of polybrominated diphenyl ethers (PBDEs) and the possible mechanisms. DNA adduction was conducted by in vitro reaction of deoxyguanosine (dG) and DNA with PBDE-quinone (PBDE-Q) metabolites, and DNA ...
Yongquan Lai +4 more
semanticscholar +1 more source