Results 331 to 340 of about 2,144,108 (379)
Some of the next articles are maybe not open access.
Toxicology Letters, 1995
The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
openaire +5 more sources
The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
openaire +5 more sources
DNA Adducts: Endogenous and Induced [PDF]
Toxicologic Pathology, 2000 Human exposure to DNA damaging agents can arise from exogenous sources or endogenous processes that occur normally or in pathological states. DNA isolated from human tissues, obtained from the very young to the old, contains detectable amounts of a number of different types of DNA adducts that reflect exposure to both known carcinogens and as yet ...
openaire +2 more sources
Measurement of DNA Adducts by Immunoassays
1990The ability to monitor for chemical carcinogen-DNA adducts in human tissues provides an indication that human exposure has occurred. Such data may eventually demonstrate the dose received and/or allow the prediction of cancer risk. At the present time evidence that the occurrence of certain adducts is associated with specific chemical exposures is ...
Eddie Reed +3 more
openaire +3 more sources
Identification of DNA Adducts of Acetaldehyde
Chemical Research in Toxicology, 2000Acetaldehyde is a mutagen and carcinogen which occurs widely in the human environment, sometimes in considerable amounts, but little is known about its reactions with DNA. In this study, we identified three new types of stable acetaldehyde DNA adducts, including an interstrand cross-link.
Edward J. McIntee +5 more
openaire +3 more sources
Carcinogenesis, 1985
Hepatocarcinogenic peroxisome proliferators, clofibrate, ciprofibrate, Wy-14643 or di(2-ethylhexyl)phthalate, were administered once daily by gavage to groups of three male F344 rats for 3 days and the rats were killed 2 h after the last dose.
Ramesh C. Gupta +4 more
semanticscholar +1 more source
Hepatocarcinogenic peroxisome proliferators, clofibrate, ciprofibrate, Wy-14643 or di(2-ethylhexyl)phthalate, were administered once daily by gavage to groups of three male F344 rats for 3 days and the rats were killed 2 h after the last dose.
Ramesh C. Gupta +4 more
semanticscholar +1 more source
Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro.
Carcinogenesis, 1984Forty-two compounds belonging to various chemical groups have been tested for their ability to suppress formation of aflatoxin B1--DNA adduct mediated by microsome in vitro. While many of these compounds have either marginal or no modulating effect, some
R. K. Bhattacharya +2 more
semanticscholar +1 more source
Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999The quantitative relationship between DNA adducts and tumor incidence is evaluated in this review. All available data on DNA adduct levels determined after repeated administration of a carcinogen to rats or mice have been compiled. The list comprised 27 chemicals, of all major structural classes of carcinogens. For the correlation with tumor incidence,
Michael Otteneder, Werner K. Lutz
openaire +3 more sources
S-[2-(N7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane.
Biochemistry, 1986The reaction of 1,2-dibromoethane and glutathione with DNA in the presence of glutathione S-transferase results in the formation of a single major DNA adduct, which can be released by thermal hydrolysis at neutral pH and separated by octadecylsilyl and ...
N. Koga +3 more
semanticscholar +1 more source
DNA adduct formation of aristolochic acid I and II in vitro and in vivo.
Carcinogenesis, 1988Aristolochic acid I (AA I) and aristolochic acid II (AA II), the two main ingredients of the carcinogenic plant extract aristolochic acid (AA), are metabolized to reactive intermediates which bind covalently to DNA in vitro and in vivo.
H. Schmeiser, K. Schoepe, M. Wiessler
semanticscholar +1 more source
2-Aminofluorene-DNA adduct formation in acetylator congenic mouse lines.
Carcinogenesis, 1989The effect of the acetylator polymorphism on hepatic 2-aminofluorene-DNA adduct formation in mice was studied using two recent developments from our laboratory.
G. Levy, W. Weber
semanticscholar +1 more source