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DNA Adducts and Carcinogenesis
1989A central tenet of cancer research is that tumors arise from cells that have undergone a permanent heritable change in their genetic material. This hypothesis originated from the observation that tumor cells have lost normal growth-control mechanisms and transmit this characteristic to their progeny. It is supported by the findings that most chemically
Miriam C. Poirier, Frederick A. Beland
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1994
Publisher Summary Redox active metal ions, such as iron and copper play a central role in the formation of reactive oxygen species in biological systems. Although iron has received the most attention in this capacity, the role of copper may be particularly crucial because copper occurs naturally in chromosomes, where it is believed to play a role in ...
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Publisher Summary Redox active metal ions, such as iron and copper play a central role in the formation of reactive oxygen species in biological systems. Although iron has received the most attention in this capacity, the role of copper may be particularly crucial because copper occurs naturally in chromosomes, where it is believed to play a role in ...
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DNA adduct assay in cervical epithelium [PDF]
Diagnostic Cytopathology, 1994 AbstractNumerous epidemiological studies have shown that there is an association between smoking and cervical cancer. However, the essential evidence to show whether this relationship is casual or causal is lacking. The demonstration of DNA modification by tobacco components in the cervical epithelium would provide biochemical evidence to support a ...
David H. Phillips +2 more
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Control of DNA Hybridization with Photocleavable Adducts
Photochemistry and Photobiology, 2005ABSTRACTPrevious reports have shown that 1‐(4,5‐dimethoxy‐2‐nitro‐phenyl)ethyl ester (DMNPE) adducts coupled to DNA plasmids block transcription in vitro and in vivo until removed with light. In this report, we explore the use of DMNPE to control DNA hybridization.
W. Todd Monroe +3 more
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Journal of Cancer Research and Clinical Oncology, 1986
Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-
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Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-
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The 32P-postlabeling assay for DNA adducts [PDF]
Nature Protocols, 2007 32P-postlabeling analysis is an ultrasensitive method for the detection and quantitation of carcinogen-DNA adducts. It consists of four principal steps: (i) enzymatic digestion of DNA to nucleoside 3'-monophosphates; (ii) enrichment of the adduct fraction of the DNA digest; (iii) 5'-labeling of the adducts by transfer of 32P-orthophosphate from [gamma ...
Phillips, David H, Arlt, Volker M
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DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.
Chemical Research in Toxicology, 2003Acrylamide (AA) is a high production volume chemical with many industrial uses; however, recent findings of ppm levels in starchy foods cooked at high temperature have refocused worldwide attention on the neurotoxicity, germ cell mutagenicity, and ...
G. Gamboa da Costa +6 more
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Measurement of a Malondialdehyde‐
AbstractDetermining the levels of various DNA adducts has become an essential tool in understanding the toxicology of carcinogens. Direct measurement of DNA adduct levels, the true biologically effective dose of a mutagen, can be correlated with biological outcomes or used to probe mechanisms of adduct formation.
Lawrence J. Marnett, John P. Plastaras
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Gold nanoprobes for detecting DNA adducts
Chem. Commun., 2014Incorporating a modified nucleobase in oligomers coupled to gold nanoparticles enables sequence specific detection of a DNA adduct.
Ioannis A. Trantakis, Shana J. Sturla
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Methods for the Detection of DNA Adducts
2011The detection and characterisation of DNA adducts can provide mechanistic information on mode of action for genotoxic chemicals and in this context is vital for human risk assessments. Adducts are measured extensively in biomonitoring studies to examine exposure to environmental, dietary, and occupational chemicals and as biomarkers of efficacy for ...
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