Results 361 to 370 of about 2,144,108 (379)

Carcinogen–DNA Adduct Formation and DNA Repair

2005
Carcinogen–DNA adducts can form following endogenous or exogenous exposure to reactive chemical species, usually electrophiles, that modify the structure of DNA. The DNA repair system comprises the products of more than 150 genes that form discrete units or an apparatus of one to eight proteins, which can detect DNA damage, effect cell cycle arrest if ...
Ainsley Weston, Miriam C. Poirier
openaire   +2 more sources

Analysis of DNA adducts in human samples: Acrolein‐derived exocyclic DNA adducts as an example

Molecular Nutrition & Food Research, 2011
AbstractAcrolein is an environmental pollutant that is also derived endogenously through lipid peroxidation and protein degradation. The reaction of acrolein with 2′‐deoxyguanosine produces exocyclic 1,N2‐propano‐2′‐deoxyguanosine (AdG) adducts, mutagenic lesions that play important roles in multistage carcinogenesis processes.
openaire   +3 more sources

Specificity of platinum–DNA adduct repair

Journal of Inorganic Biochemistry, 1999
Cell lines with resistance to cisplatin and carboplatin often retain sensitivity to platinum complexes with different carrier ligands (e.g., oxaliplatin and JM216). HeLa cell extracts were shown to excise cisplatin, oxaliplatin, and JM216 adducts with equal efficiency, suggesting that nucleotide excision repair does not contribute to the carrier-ligand
Alexandra Vaisman, Stephen G. Chaney
openaire   +3 more sources

DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase.

Carcinogenesis, 1995
8-Hydroxyl-2'-deoxyguanosine (also referred to as 8-hydroxyguanine [8-OH-dG] or 7,8-dihydro-8-oxoguanine), a common DNA adduct resulting from injury to DNA via reactive oxygen species, affects the in vitro methylation of nearby cytosine moieties by the ...
P. Turk, Ali Laayoun, Steven S. Smith, Sigmund A. Weitzman   +3 more
semanticscholar   +1 more source

DNA Adducts in Cancer Chemotherapy

Journal of Medicinal Chemistry
DNA adducting drugs, including alkylating agents and platinum-containing drugs, are prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction with DNA, resulting in the formation of DNA addition products known as DNA adducts. While these adducts are well-accepted to induce cancer cell death, understanding of their specific
openaire   +2 more sources

Immunologic Quantification of Carcinogen-DNA Adducts

1986
Sensitive immunological methods for the detection of carcinogen-DNA adducts have recently been developed. These techniques are particularly useful for screening human populations for exposure to environmental carcinogens. Measurement of the biologically effective dose in humans may be useful in detecting carcinogenic hazards and carrying out risk ...
Ling-Ling Hsieh, Frederica P. Perera, Regina M. Santella   +2 more
openaire   +3 more sources

Detection of human DNA–carcinogen adducts

Nature, 1992
The role of specific chemicals in the aetiology of human cancer can now be assessed using 32P-postlabelling in combination with corroborative biomonitoring techniques.
openaire   +3 more sources

The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats

Archives of Toxicology, 2014
M. Stiborová, F. Bárta, K. Levova, P. Hodek, E. Frei, V. Arlt, H. Schmeiser   +6 more
semanticscholar   +1 more source

DNA Adducts and Their Biological Relevance

1984
Epidemiologic studies of human carcinogenesis have demonstrated that exposure to certain chemicals significantly increases cancer risks. Additionally, the carcinogenic effects of chemicals have been observed in many animal experiments. As a result of these studies, strong regulations have been imposed worldwide to limit exposure to chemical carcinogens,
F. Oesch, G. Doerjer, M. A. Bedell
openaire   +2 more sources

DNA adducts of epoxybutene

Mutation Research/Environmental Mutagenesis and Related Subjects, 1992
E. Marafante, C. Leuratti
openaire   +2 more sources