Results 31 to 40 of about 2,144,108 (379)

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]

open access: yes, 2012
Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Austin, Caroline   +10 more
core   +3 more sources

In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling.

open access: yesMutagenesis, 2012
Estragole is a naturally occurring food-borne genotoxic compound found in a variety of food sources, including spices and herbs. This results in human exposure to estragole via the regular diet.
A. Paini   +8 more
semanticscholar   +1 more source

Sperm DNA oxidative damage and DNA adducts [PDF]

open access: yesMutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015
The objective of this study was to investigate DNA damage and adducts in sperm from coke oven workers who have been exposed to polycyclic aromatic hydrocarbons. A longitudinal study was conducted with repeated measurements during spermatogenesis. Coke-oven workers (n=112) from a coke-oven plant served the PAH-exposed group, while administrators and ...
Jeng, Hueiwang Anna   +3 more
openaire   +4 more sources

Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair

open access: yesNature Communications, 2021
The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure
Trevor van Eeuwen   +8 more
doaj   +1 more source

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells [PDF]

open access: yes, 2011
Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis.
Carell, Thomas   +14 more
core   +4 more sources

Unusual DNA binding modes for metal anticancer complexes [PDF]

open access: yes, 2009
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core   +1 more source

Quantitative comparison between in vivo DNA adduct formation from exposure to selected DNA-reactive carcinogens, natural background levels of DNA adduct formation and tumour incidence in rodent bioassays.

open access: yesMutagenesis, 2011
This study aimed at quantitatively comparing the occurrence/formation of DNA adducts with the carcinogenicity induced by a selection of DNA-reactive genotoxic carcinogens.
A. Paini   +6 more
semanticscholar   +1 more source

Method Development and Validation for Measuring O6-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry

open access: yesDrug Design, Development and Therapy, 2021
Yahdiana Harahap,1,2 Aurelia Maria Vianney,1 Herman Suryadi1 1Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia; 2Indonesia Defense University, Bogor, 16810, West Java, IndonesiaCorrespondence: Yahdiana Harahap Email yahdiana@
Harahap Y, Vianney AM, Suryadi H
doaj  

Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ [PDF]

open access: yes, 1990
2,5-Bis(1-aziridinyl)-1,4-benzoquinone (BABQ) is a compound from which several antitumour drugs are derived, such as Trenimone, Carboquone and Diaziquone (AZQ).
Egberink, Richard J.M.   +5 more
core   +2 more sources

Polycyclic Aromatic Hydrocarbon (PAH) Exposure and DNA Adduct Semi-Quantitation in Archived Human Tissues

open access: yesInternational Journal of Environmental Research and Public Health, 2011
Polycyclic aromatic hydrocarbons (PAHs) are combustion products of organic materials, mixtures of which contain multiple known and probable human carcinogens. PAHs occur in indoor and outdoor air, as well as in char-broiled meats and fish. Human exposure
M. Pratt   +5 more
semanticscholar   +1 more source

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