Results 51 to 60 of about 2,144,108 (379)

DNA Damage and the Gut Microbiome: From Mechanisms to Disease Outcomes

open access: yesDNA, 2023
Both the number of cells and the collective genome of the gut microbiota outnumber their mammalian hosts, and the metabolic and physiological interactions of the gut microbiota with the host have not yet been fully characterized.
Yun-Chung Hsiao   +5 more
doaj   +1 more source

Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides [PDF]

open access: yes, 2010
We show that UVA irradiation (365 nm) of the Pt-IV complex trans,trans,trans-[(PtCl2)-Cl-IV(OH)(2)(dimethylamine) (isopropylamine)] (1), induces reduction to Pt-II photoproducts.
Cubo, Leticia   +5 more
core   +1 more source

DNA adduct profiling of in vitro colonic meat digests to map red vs. white meat genotoxicity

open access: yes, 2018
The consumption of red meat has been linked to an increased colorectal cancer (CRC) risk. One of the major hypotheses states that heme iron (present in red meat) stimulates the formation of genotoxic N-nitroso compounds (NOCs) and lipid peroxidation ...
De Paepe, Ellen   +3 more
core   +1 more source

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion [PDF]

open access: yes, 2014
This work was supported by US Public Health Service grant AI054961 (GEW/NJW), a University Research Fellowship from the Royal Society (NJW) and funding for the mass spectrometry analysis was provided by the Vermont Genetics Network/NIH Grant 8P20GM103449
Ballif, B.A.   +7 more
core   +3 more sources

Evaluation of the Mechanisms Involved in the Development of Bladder Toxicity following Exposure to Occupational Bladder Cancer Causative Chemicals Using DNA Adductome Analysis

open access: yesBiomolecules, 2023
Occupational exposure to aromatic amines (AAs) is an important risk factor for urinary bladder cancer. This study aimed to evaluate the toxicity of AAs and analyze the carcinogenic mechanisms in rat bladder by comprehensive analysis of DNA adducts (DNA ...
Shugo Suzuki   +8 more
doaj   +1 more source

32P-Postlabeling analysis of IQ, MelQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MelQx- and PhIP-treated monkeys [PDF]

open access: yes, 1993
The P-32-postlabeling method was used to examine the adducts in DNA, polynucleotides, and mononucleotides reacted in vitro with the N-hydroxy and N-acetoxy derivatives of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3, 8-dimethylimidazo[4,5-f ...
Davis, Cindy D.   +4 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Analysis of Structural Flexibility of Damaged DNA Using Thiol-Tethered Oligonucleotide Duplexes. [PDF]

open access: yesPLoS ONE, 2015
Bent structures are formed in DNA by the binding of small molecules or proteins. We developed a chemical method to detect bent DNA structures. Oligonucleotide duplexes in which two mercaptoalkyl groups were attached to the positions facing each other ...
Masashi Fujita   +4 more
doaj   +2 more sources

Response to Comments of Peter G. Mantle

open access: yesToxins, 2010
The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats.
Richard A. Manderville   +2 more
doaj   +1 more source

Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides

open access: yesGenes and Environment, 2021
Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guanosine led to ...
F. Peter Guengerich, Pratibha P. Ghodke
doaj   +1 more source

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