Results 61 to 70 of about 33,588 (237)

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Effect of supplemental lactic acid bacteria on growth performance, glutathione turnover and aflatoxin B1 removal in lambs

Czech Journal of Animal Science, 2019
This study investigated the effect of lactic acid bacteria (LAB) on growth performance, glutathione turnover, aflatoxin B1 (AFB1) residue and AFB1-DNA adduct in growing lambs.
Jianping Wang, Lin Lin, Qingrong Jiang, Wanli Huang, Ning Liu   +4 more
doaj   +1 more source

Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis

Advanced Science, EarlyView.
Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan, Yunping Chen, Wei Zhou, Yanghong Xu, Junran Huang, Yi Chen, Jizhou Meng, Guoxin Yao, Wenchao Huang   +8 more
wiley   +1 more source

Association of age at pancreatic cancer diagnosis with smoking and drinking: A hospital‐based and meta‐analysis study

Advances in Digestive Medicine, EarlyView.
Abstract Recent trends show an alarming rise in pancreatic cancer prevalence among young individuals. Previous studies have presented differences in age at diagnosis. The study aimed to examine the likelihood of a younger age at diagnosis in individuals exposed to known risk factors, compared with those without exposure.
Ro‐Ting Lin, Louise E. Anthony, Hathaichon Inchai, Lung‐Chang Chien, Chun‐Chieh Yeh, Chi‐Ying Yang, Jaw‐Town Lin   +6 more
wiley   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

Journal of Nucleic Acids, 2010
DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DNAPs, which are mostly in the Y-Family. Y-Family DNAPs can do non-mutagenic or mutagenic dNTP insertion, and understanding this difference is important ...
Sushil Chandani, Christopher Jacobs, Edward L. Loechler   +2 more
doaj   +1 more source

Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa

Gut Microbes
Colibactin is a recently characterized pro-carcinogenic genotoxin produced by pks+ Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus structure increases the vulnerability of host mucosa to colibactin-induced DNA ...
Amanda Mandarino Alves, Chiara Lecchi, Sharon Lopez, Alessia Stornetta, Prince P. Mathai, Peter W. Villalta, Satoshi Ishii, Emily P. Balskus, Silvia Balbo, Alexander Khoruts   +9 more
doaj   +1 more source

Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

Particle and Fibre Toxicology, 2009
Titanium dioxide (TiO2), also known as titanium (IV) oxide or anatase, is the naturally occurring oxide of titanium. It is also one of the most commercially used form.
Schins Roel PF, Boertz Jens, Davoren Maria, Bhattacharya Kunal, Hoffmann Eik, Dopp Elke   +5 more
doaj   +1 more source

Transcription Factor Inhibition as a Potential Additional Mechanism of Action of Pyrrolobenzodiazepine (PBD) Dimers

DNA
Background: The pyrrolobenzodiazepine (PBD) dimer SJG-136 reached Phase II clinical trials in ovarian cancer and leukaemia in the UK and USA in the 2000s.
Julia Mantaj, Paul J. M. Jackson, Richard B. Parsons, Tam T. T. Bui, David E. Thurston, Khondaker Miraz Rahman   +5 more
doaj   +1 more source