Results 61 to 70 of about 2,144,108 (379)

Synthesis, reactivity studies, and cytotoxicity of two trans-Iodidoplatinum(II) complexes. Does photoactivation work? [PDF]

open access: yes, 2018
trans-Platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin.
Carnero Moya, Amancio   +5 more
core   +1 more source

DNA adducts, mutations and cancer [PDF]

open access: yesCarcinogenesis, 1993
Anyone having lectured on DNA adducts is likely to be familiar with the first question after the presentation: 'What is the relationship of DNA adducts and cancer?'. Although there are a number of reviews on the topic (1-5), my personal response, instead of going into lengthy circumstantial argumentation and hand-waving, has been a quotation from ...
openaire   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts. [PDF]

open access: yes, 2016
Enzymatic approaches for locating alkylation adducts at single-base resolution in DNA could enable new technologies for understanding carcinogenesis and supporting personalized chemotherapy.
Andreas Marx   +6 more
core   +2 more sources

DNA adducts of chemical carcinogens [PDF]

open access: yesCarcinogenesis, 1995
Introduction During the 30 years or so following the identification of the first pure chemical carcinogen (1), no common factors or pathways in the mechanism of action of carcinogens from different chemical classes were evident. For this reason perhaps, each class of carcinogen, e.g.
openaire   +3 more sources

Metabolism of benzo[a]pyrene by human mammary epithelial cells: toxicity and DNA adduct formation.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1981
Pure cultures of human breast epithelial cells and of fibroblastic cells in early passage provided the opportunity to ask whether either cell type had the capability for metabolizing chemical carcinogens and, if so, was the fate of the metabolic products
M. Stampfer   +3 more
semanticscholar   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

open access: yesAdvanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Induction of epstein-barr virus (EBV) lytic cycle in vitro causes lipid peroxidation, protein oxidation and DNA damage in lymphoblastoid B cell lines

open access: yesLipids in Health and Disease, 2011
Background We investigated the oxidative modifications of lipids, proteins and DNA, potential molecular targets of oxidative stress, in two lymphoblastoid cell lines: B95-8 and Raji, after EBV lytic cycle induction.
benmansour Riadh   +4 more
doaj   +1 more source

Photoactivatable organometallic pyridyl ruthenium(II) arene complexes [PDF]

open access: yes, 2012
The synthesis and characterization of a family of piano-stool RuII arene complexes of the type [(η6-arene)Ru(N,N′)(L)][PF6]2, where arene is p-cymene (p-cym), hexamethylbenzene (hmb), or indane (ind), N,N′ is 2,2′-bipyrimidine (bpm), 1,10-phenanthroline (
Betanzos-Lara, Soledad   +8 more
core   +1 more source

Quantitative comparison of genetic effects of ethylating agents on the basis of DNA adduct formation. Use of O6-ethylguanine as molecular dosimeter for extrapolation from cells in culture to the mouse.

open access: yesEnvironmental Health Perspectives, 1985
DNA-adduct formation and induction of gene mutations were determined simultaneously after treatment with the four ethylating agents, ethyl methanesulfonate (EMS), ethylnitrosourea (ENU), diethyl sulfate (DES), and N-ethyl-N'-nitro-N-nitrosoguanidine ...
A. V. van Zeeland   +3 more
semanticscholar   +1 more source

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