Results 71 to 80 of about 40,057 (283)

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis

Advanced Science, EarlyView.
Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan, Yunping Chen, Wei Zhou, Yanghong Xu, Junran Huang, Yi Chen, Jizhou Meng, Guoxin Yao, Wenchao Huang   +8 more
wiley   +1 more source

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

Journal of Nucleic Acids, 2010
DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DNAPs, which are mostly in the Y-Family. Y-Family DNAPs can do non-mutagenic or mutagenic dNTP insertion, and understanding this difference is important ...
Sushil Chandani, Christopher Jacobs, Edward L. Loechler   +2 more
doaj   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa

Gut Microbes
Colibactin is a recently characterized pro-carcinogenic genotoxin produced by pks+ Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus structure increases the vulnerability of host mucosa to colibactin-induced DNA ...
Amanda Mandarino Alves, Chiara Lecchi, Sharon Lopez, Alessia Stornetta, Prince P. Mathai, Peter W. Villalta, Satoshi Ishii, Emily P. Balskus, Silvia Balbo, Alexander Khoruts   +9 more
doaj   +1 more source

Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

Particle and Fibre Toxicology, 2009
Titanium dioxide (TiO2), also known as titanium (IV) oxide or anatase, is the naturally occurring oxide of titanium. It is also one of the most commercially used form.
Schins Roel PF, Boertz Jens, Davoren Maria, Bhattacharya Kunal, Hoffmann Eik, Dopp Elke   +5 more
doaj   +1 more source

A computational study of the structures and base-pairing properties of pyrrolizidine alkaloid-derived DNA adducts

, 2023
Mckenzie Franz, Melanie S. Kebel, Pardeepak S. Sandhu, Denisa Moldovan, Taylor P. K. Adamitz, Rajwinder Kaur, Ye Eun Rebecca Jeong, Stacey D. Wetmore   +7 more
openalex   +1 more source

Transcription Factor Inhibition as a Potential Additional Mechanism of Action of Pyrrolobenzodiazepine (PBD) Dimers

DNA
Background: The pyrrolobenzodiazepine (PBD) dimer SJG-136 reached Phase II clinical trials in ovarian cancer and leukaemia in the UK and USA in the 2000s.
Julia Mantaj, Paul J. M. Jackson, Richard B. Parsons, Tam T. T. Bui, David E. Thurston, Khondaker Miraz Rahman   +5 more
doaj   +1 more source

O⁶‐carboxymethylguanine DNA adduct formation and lipid peroxidation upon in vitro gastrointestinal digestion of haem‐rich meat [PDF]

, 2014
Julie Vanden Bussche, Lieselot Hemeryck, Thomas Van Hecke, Gunter Kuhnle, Frank Pasmans, Sharon A. Moore, Tom Van de Wiele, Stefaan De Smet, Lynn Vanhaecke   +8 more
openalex   +1 more source

Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA

Toxins, 2010
Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jamie E. Jennings-Gee, Mariana Tozlovanu, Richard Manderville, Mark Steven Miller, Annie Pfohl-Leszkowicz, Gary G. Schwartz   +5 more
doaj   +1 more source