Results 131 to 140 of about 2,409,493 (295)

Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance. [PDF]

Nucleic Acids Res, 2022
Chen X, Bradley NP, Lu W, Wahl KL, Zhang M, Yuan H, Hou XF, Eichman BF, Tang GL.   +8 more
europepmc   +1 more source

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells. [PDF]

Carcinogenesis, 2022
Chen KM, Sun YW, Krebs NM, Sun D, Krzeminski J, Reinhart L, Gowda K, Amin S, Mallery S, Richie JP, El-Bayoumy K.   +10 more
europepmc   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

The Relationship between Exposure to Airborne Particulate and DNA Adducts in Blood Cells in an Urban Population of Subjects with an Unhealthy Body Mass Index. [PDF]

Int J Environ Res Public Health, 2022
Pulliero A, Iodice S, Pesatori AC, Vigna L, Khalid Z, Bollati V, Izzotti A.   +6 more
europepmc   +1 more source

Stepwise mitochondria‐targeted photodynamic immunotherapy enabled by an outer membrane vesicles‐based nanoplatform for synergistic tumor ablation and immune reprogramming

Smart Molecules, EarlyView.
We constructed a novel excellent photodynamic drug without heavy atoms based on the conventional BODIPY photosensitizer, and then obtained a photodynamic vesicle with efficient tumor targeting (BDPM@OMVs) by bacterial extravasation. Multiple reactive oxygen species were efficiently generated under light irradiation, and the spontaneous elimination of ...
Xiang Cheng, Ziheng Luo, Ying Yin, Duoyang Fan, Ruyan Xie, Yanpeng Fang, Xiaohui Liu, Dayan Xiong, Wei Liu, Seraphine V. Wegner, Fei Chen, Wenbin Zeng   +11 more
wiley   +1 more source

Synthesis of Oligonucleotides Containing Trans Mitomycin C DNA Adducts at N⁶ of Adenine and N² of Guanine. [PDF]

Chemistry, 2021
Zacarias O, Petrovic AG, Abzalimov R, Pradhan P, Champeil E.   +4 more
europepmc   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Reassessing the Significance of Chromium-DNA Adducts in Chromate Carcinogenicity. [PDF]

Biol Trace Elem Res
Vincent JB.
europepmc   +1 more source