Results 131 to 140 of about 53,252 (284)

Formation of DNA adducts and induction of mutations in rats treated with tumorigenic doses of 1,6-dinitropyrene. [PDF]

, 1994
Frederick A. Beland, Nancy F. Fullerton, Bruce A. Smith, Robert H. Heflich   +3 more
openalex   +1 more source

Chemoenzymatic Route toward a De Novo Enantioselective Total Synthesis of (S)‐Baclofen Based on Metal‐Catalyzed Hydroformylation and Enzymatic Transamination

ChemBioChem, EarlyView.
A unique chemoenzymatic synthesis route toward (S)‐baclofen is presented, which highlights a hydroformylation and biocatalysis step toward the synthesis of such a challenging β‐chiral amino acid. The shown methodology exhibits high conversions and enantiomeric excess and is transferable to other β‐chiral amines and amino acids.
Feodor Belov, Hannah Bork, Luise Hänel, Manideep V. Kollipara, Matthias Höhne, Harald Gröger, Jan von Langermann   +6 more
wiley   +1 more source

Quantitation of DNA Adducts Resulting from Acrolein Exposure and Lipid Peroxidation in Oral Cells of Cigarette Smokers from Three Racial/Ethnic Groups with Differing Risks for Lung Cancer. [PDF]

Chem Res Toxicol, 2022
Park SL, Le Marchand L, Cheng G, Balbo S, Chen M, Carmella SG, Thomson NM, Lee Y, Patel YM, Stram DO, Jensen J, Hatsukami DK, Murphy SE, Hecht SS.   +13 more
europepmc   +1 more source

Antibodies to Carcinogen-DNA Adducts [PDF]

JNCI: Journal of the National Cancer Institute, 1981
openaire   +3 more sources

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

ChemBioChem, Accepted Article.
The ubiquitin (Ub) system governs vital cellular processes in eukaryotic biology through an intricate network of Ub‐protein interactions. While semisynthetic C‐terminal Ub electrophiles (UbEs) are widely used to study Ub transfer and deubiquitinase (Dub) activity, they are limited to probing the active site while leaving other functionally important ...
Chittaranjan Das, Nipuni M. Pannala, Rishi S. Patel, Abhijith Saseendran Anit, Debapriya Bhattacharya, Kristos Negron Teron, Bryon Drown, Rudi Fasan   +7 more
wiley   +1 more source

Comprehensive Analysis of DNA Adducts Using Data-Independent wSIM/MS² Acquisition and wSIM-City. [PDF]

Anal Chem, 2021
Walmsley SJ, Guo J, Murugan P, Weight CJ, Wang J, Villalta PW, Turesky RJ.   +6 more
europepmc   +1 more source

32 P Analysis of DNA Adducts in Tissues of Benzene-Treated Rats

, 1989
M. Vijayaraj Reddy, Gary R. Blackburn, Ceinwen A. Schreiner, Myron A. Mehlman, Carl R. Mackerer   +4 more
openalex   +1 more source

Synthesis and Evaluation of Trehalose‐Based Mertansine Warheads for Bacillus Calmette–Guérin Delivery of Anticancer Agents

ChemBioChem, EarlyView.
Bacillus Calmette–Guérin (BCG) immunotherapy is the gold standard for nonmuscle invasive bladder cancer (NMIBC). However, it is limited by adverse effects and resistance, despite eliciting a robust immune response. This proof‐of‐concept study explores Antigen 85‐mediated, metabolically with trehalose‐PEG4 mertansine‐labeled BCG as a novel treatment ...
Michael Grimmeisen, Xuan Wang, Melissa Weldle, Kerstin Sartory, Sara Benkhelifa, Yu Zhang, Trinh Dao, Jonas Meyer, Oliver Gorka, Olaf Groß, Claudia Jessen‐Trefzer   +10 more
wiley   +1 more source

Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct. [PDF]

, 1991
Ying‐Duo Gao, Yen‐Chywan Liaw, Y K Li, G. A. VAN DER MAREL, J. H. VAN BOOM, Andrew H.‐J. Wang   +5 more
openalex   +1 more source

Gold‐Dithiocarbamato Glycoconjugates as Potential Anticancer Agents: Design, Physico‐Chemical Characterization and In Vitro Biological Activity

ChemBioChem, Accepted Article.
In order to develop new metal‐based glycoconjugates as potential anticancer agents, three gold(III)‐dithiocarbamato glycoconjugates of the type [AuIIIBr2(SSC‐Inp‐GlcN)] (Au3‐5), their gold(I)‐phosphine counterparts [AuI(SSC‐Inp‐GlcN)(PPh3)] (AuP3‐5) and gold(I)‐carbene analogues [AuI(SSC‐Inp‐GlcN)(Et2BzImy)] (AuC3‐5) (Inp: isonipecotic moiety; GlcN ...
Andrea Pettenuzzo, Jessica Wölker, Luciano Marchiò, Ingo Ott, Luca Ronconi   +4 more
wiley   +1 more source