Results 151 to 160 of about 53,252 (284)

Measurement of chromosomal aberrations, sister chromatid exchange, hprt mutations, and DNA adducts in peripheral lymphocytes of human populations at increased risk for cancer [PDF]

, 1993
David Jacobson‐Kram, Richard J. Albertini, Richard F. Branda, Michael T. Falta, P. Thomas Iype, Ken Kolodner, Saou-Hsing Liou, Melissa A. McDiarmid, Marcia A. Morris, Janice A. Nicklas, J. Patrick O'Neill, Miriam C. Poirier, Donald L. Putman, Paul T. Strickland, Jerry R. Williams, Shuqin Xiao   +15 more
openalex   +1 more source

Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology

Eye &ENT Research, EarlyView.
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang, Xiaoyu Song, Fengxin Yang, Huhuifen He, Kun Zhao, Jingjing Qiu, Limei Cui, Qiang Zhang, Limei Liu, Yan Sun   +9 more
wiley   +1 more source

DNA adducts form in mouse lung and liver after oral naphthalene exposure. [PDF]

Toxicol Sci
Domanico MC, Collette NM, Ubick E, Ding X, Buchholz BA, Van Winkle LS.   +5 more
europepmc   +1 more source

Polycyclic Aromatic Hydrocarbon-DNA Adducts in Gulf of Mexico Sperm Whale Skin Biopsies Collected in 2012. [PDF]

Toxicol Sci, 2021
Poirier MC, Marsili L, Fossi MC, Godard-Codding CAJ, Hernandez-Ramon EE, Si N, Divi KV, Divi RL, Kerr I, Wise JP, Wise CF, Wise SS, Aboueissa AE, Wise JTF, Wise JP.   +14 more
europepmc   +1 more source

Gilvocarcin V exhibits both equilibrium DNA binding and UV light induced DNA adduct formation which is sequence context dependent [PDF]

, 1992
Robert Knobler, Bernhard Radlwimmer, Michael J. Lane   +2 more
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Effect of methyl DNA adducts on 3'-5' exonuclease activity of human TREX1. [PDF]

Biochem J
Tuti N, Shaji UP, Das S, Anindya R.
europepmc   +1 more source

Analysis of 4-aminobiphenyl-DNA adducts in human urinary bladder and lung by alkaline hydrolysis and negative ion gas chromatography-mass spectrometry.

, 1994
Dongxin Lin, Jackson O. Lay, Matthew Bryant, C. Malaveille, Marlin D. Friesen, Helmut Bartsch, Nicholas P. Lang, Fred F. Kadlubar   +7 more
openalex   +1 more source

Improved immunocytochemical staining of carcinogen-DNA adducts by a capillary slot block system. [PDF]

, 1990
E. Scherer, Jan van Benthem
openalex   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source