Results 161 to 170 of about 53,252 (284)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

open access: yesExploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu   +5 more
wiley   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

open access: yesExploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang   +4 more
wiley   +1 more source

Mutational properties of the primary aflatoxin B1-DNA adduct. [PDF]

open access: green, 1996
Eric Bailey   +4 more
openalex   +1 more source

Puerariae lobatae Radix Alleviates Alcoholic Liver Injury by Regulating Circadian Rhythm and Intestinal Flora

open access: yesFood Frontiers, EarlyView.
(A) PLR contains a variety of isoflavones; (B) PLR attenuated alcoholic liver injury; (C) PLR improved intestinal flora dysbiosis; (D) PLR regulated circadian rhythm. ABSTRACT This study used Puerariae lobatae Radix (PLR) to explore its improvement mechanism in mice with alcoholic liver injury from the perspective of intestinal flora and transcriptome.
Yanfang Liao   +7 more
wiley   +1 more source

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