Results 211 to 220 of about 2,409,493 (295)

Naphthalene genotoxicity: DNA adducts in primate and mouse airway explants. [PDF]

Toxicol Lett, 2019
Carratt SA, Hartog M, Buchholz BA, Kuhn EA, Collette NM, Ding X, Van Winkle LS.   +6 more
europepmc   +1 more source

Dietary Carcinogens and DNA Adducts in Prostate Cancer. [PDF]

Adv Exp Med Biol, 2019
Bellamri M, Turesky RJ.
europepmc   +1 more source

DFTB Parametrization at the Example of Platinum—Implementation, Validation and Practical Considerations

Journal of Computational Chemistry, Volume 47, Issue 7, March 15, 2026.
Development and comprehensive validation of 3ob‐compatible DFTB3 parameters for platinum, enabling efficient and reliable simulations of a wide range of Pt‐containing systems. ABSTRACT Practical considerations for the parametrization of the transition metal platinum within the third‐order density‐functional tight‐binding (DFTB3) method are presented ...
Felix R. S. Purtscher, Armin Penz, Josef M. Gallmetzer, Jakob Gamper, Thomas S. Hofer   +4 more
wiley   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Photochemical Aerobic Upcycling of Polystyrene Plastics via Indium Salt‐Mediated Synergistic Catalysis

ChemSusChem, Volume 19, Issue 5, 13 March 2026.
This study presents a practical aerobic photochemical strategy for the upcycling of polystyrene waste, combining bromine radical mediation with InBr3 catalysis. The approach efficiently depolymerizes diverse PS materials under mild conditions, yielding benzoic acid and enabling downstream production of value‐added compounds. The photochemical upcycling
Lydia Lavrenti, Christos Papagkikas, Olga G. Mountanea, Christoforos G. Kokotos   +3 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, Volume 600, Issue 6, Page 910-938, March 2026.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, Volume 20, Issue 3, Page 688-708, March 2026.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cancer‐associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi‐omics and machine learning analysis

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer‐associated fibroblasts (aCAFs) on survival outcomes and immune responses and examined their association with various ...
Myungsun Shim, One‐Zoong Kim, Byoung Kwan Son, Jung Ki Jo, Seung Wook Lee, Hong Sang Moon, Hyung Suk Kim, Mi Jung Kwon, Sung Hak Lee, Yung‐Kyun Noh, Kyueng‐Whan Min   +10 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, Volume 16, Issue 3, Page 584-594, March 2026.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

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DNA Adducts in Cancer Chemotherapy

Journal of Medicinal Chemistry
DNA adducting drugs, including alkylating agents and platinum-containing drugs, are prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction with DNA, resulting in the formation of DNA addition products known as DNA adducts. While these adducts are well-accepted to induce cancer cell death, understanding of their specific
Yupeng Li
openaire   +3 more sources