Results 211 to 220 of about 53,252 (284)

Anti‐Cancer Potential of Copper‐NTB Complex via Damaging Cellular Organelles and Apoptosis in Triple‐Negative Breast Cancer Therapy

Nano Select, EarlyView.
Summarizes the dose‐dependent anti‐cancer activity of copper(Cu)‐tris((1H‐benzo[d]imidazol‐2‐yl)methyl)amine (NTB) or [Cu(NTB)(OH2)](ClO4)2 or Cu‐NTB complex against MDA‐MB‐231 breast cancer cells via apoptosis, DNA damage, lysosomal membrane permeabilization, and mitochondrial dysfunction.
Sri Renukadevi Balusamy, Mani Balamurugan, Sagnik Nag, Sourav Mohanto, Mohamed Farouk Elsadek, Nojood Altwaijry, Daewon Sohn, Ivan Mijakovic, Priyanka Singh, Haribalan Perumalsamy   +9 more
wiley   +1 more source

Nephroprotective Effects of Fraxinus Hookeri Wenz. Against Renal Toxicity and DNA Oxidative Damages Induced by CCl4 in Rats

ChemistryOpen, EarlyView.
This study evaluates the nephroprotective potential of Fraxinus hookeri Wenz. (F. hookeri), a medicinal plant of the Oleaceae family, against CCl4‐induced oxidative stress. The findings demonstrate its ability to restore antioxidant defenses, renal function markers, and DNA integrity while reducing lipid peroxidation and histopathological damage.
Raheela Sarwar, Bashir Ahmad, Ayman M. Al‐Qaaneh, Shumaila Rauf, Laiba Ahmad, Mounir M. Bekhit, Said Hassan, Nadeem Ullah, Gokhan Zengin, Arshad Farid   +9 more
wiley   +1 more source

Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy. [PDF]

Free Radic Biol Med, 2020
Miyajima T, Melangath G, Zhu S, Deshpande N, Vasanth S, Mondal B, Kumar V, Chen Y, Price MO, Price FW, Rogan EG, Zahid M, Jurkunas UV.   +12 more
europepmc   +1 more source

The Impact of Conjugation Mode and Site on Tubulysin Antibody‐Drug‐Conjugate Efficacy and Stability

ChemistryOpen, EarlyView.
Two biotransformation events, payload metabolism and deconjugation, are profiled using immuno‐capture ligand‐binding assays and mass spectrometry. The site‐specific antibody‐drug conjugate (ADC) demonstrates superior in vivo efficacy and favorable pharmacokinetics compared to site‐directed or random ADCs.
Sayumi Yamazoe, Qinqin Cheng, Srikanth Kotapati, Vangipuram S. Rangan, Mei‐Chen Sung, Madhura Deshpande, Aarti Jashnani, Cong Qiang, Michael J. Smith, Chin Pan, Gavin Dollinger, Arvind Rajpal, Pavel Strop, Chetana Rao   +13 more
wiley   +1 more source

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. [PDF]

Nat Commun, 2020
Fielden J, Wiseman K, Torrecilla I, Li S, Hume S, Chiang SC, Ruggiano A, Narayan Singh A, Freire R, Hassanieh S, Domingo E, Vendrell I, Fischer R, Kessler BM, Maughan TS, El-Khamisy SF, Ramadan K.   +16 more
europepmc   +1 more source

Formation and persistence of DNA adducts in different target tissues of rats after multiple administration of benzo[a]pyrene

, 1996
Shu-Xin Qu, Neill H. Stacey
openalex   +1 more source

Synthesis and Anticancer Potential of New Benzimidazole Theranostic

ChemistryOpen, EarlyView.
Recent advances have highlighted benzimidazole's importance in anticancer drug discovery. A novel series of benzimidazole analogs is designed and synthesized, with V7 showing broad anticancer activity and selectivity, possibly linked to SIRT2 inhibition.
Sahani Sandalima Uthumange, Muhammad Azri Faiz bin Abdul Zaki, Keng Yoon Yeong   +2 more
wiley   +1 more source

Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci, 2020
Totsuka Y, Maesako Y, Ono H, Nagai M, Kato M, Gi M, Wanibuchi H, Fukushima S, Shiizaki K, Nakagama H.   +9 more
europepmc   +1 more source

Anti‐Inflammatory Saponins From an Edible Aquatic Plant Nymphoides hydrophylla

Phytochemical Analysis, EarlyView.
ABSTRACT Introduction The present investigation of Nymphoides hydrophylla is a Taiwan indigenous edible aquatic plant, belongs to the Menyanthaceae family, and has been used as a traditional food with potential medicinal values against fever, insect bites, ulcer, and skin diseases.
Ching‐Yeu Chen, Tzu‐Peng Cheng, Tsong‐Long Hwang, Yong‐Siang Hou, Limbadri Salendra, Tzi‐Yi Ke, Yuan‐Bin Cheng   +6 more
wiley   +1 more source

Genetic Diagnosis and Clinical Features of Fetuses With Congenital Diaphragmatic Hernia

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Congenital diaphragmatic hernia (CDH) is a rare abnormality with highly heterogeneous genetic causes. This study investigated chromosomal and monogenic abnormalities in fetal CDH patients and evaluated the efficacy of chromosomal microarray analysis (CMA) and whole‐exome sequencing (WES) for genetic diagnosis.
Yan Lü, Yi Yu, Jiazhen Chang, Mengmeng Li, Xueting Yang, Xiya Zhou, Na Hao, Hua Meng, Zhenghong Li, Lishuang Ma, Hui You, Shan Jian, Ying Wang, Shengjie Li, Yiqing Yu, Kaili Yin, Mingming Wang, Yulin Jiang, Qingwei Qi   +18 more
wiley   +1 more source