Results 221 to 230 of about 2,409,493 (295)
Some of the next articles are maybe not open access.
Medical Hypotheses, 2019
DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
B K, Puri, C, Ijeh, J A, Monro
openaire +2 more sources
DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
B K, Puri, C, Ijeh, J A, Monro
openaire +2 more sources
Toxicology, 1995
Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
K, Hemminki, H, Autrup, A, Haugen
openaire +2 more sources
Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
K, Hemminki, H, Autrup, A, Haugen
openaire +2 more sources
Toxicology Letters, 1995
The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
openaire +3 more sources
The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
openaire +3 more sources
DNA adducts of halogenated hydrocarbons
Journal of Cancer Research and Clinical Oncology, 1986Although formation of DNA adducts has been postulated for several halomethanes, no chemical identification of such adducts has been performed so far. There is, however, evidence that methyl chloride does not act biologically as a DNA methylating agent. 1,2-Dichloroethane and 1,2-dibromoethane are activated through conjugation with glutathione. There is
H M, Bolt +3 more
openaire +2 more sources
DNA Adduct-Directed Synthetic Nucleosides
Accounts of Chemical Research, 2019Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O6-alkylguanine ( O6-alkylG) DNA adducts are strongly miscoding during DNA replication when the damaged nucleobase is a template for polymerase-mediated translesion DNA synthesis.
Michael H. Räz +3 more
openaire +2 more sources
DNA adducts in bronchial biopsies
International Journal of Cancer, 1991AbstractTo investigate the feasibility of measuring DNA‐carcinogen adducts in the lungs of non‐surgical patients, endobronchial biopsies were obtained from 78 patients undergoing routine diagnostic bronchoscopy. Lung cancer was present in 37 (47%) of the patients.
B P, Dunn +6 more
openaire +2 more sources
DNA adducts from chemotherapeutic agents
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1996The guiding principle of early work was the hypothesis that the anti-cancer alkylating drugs acted through their ability to cross-link macromolecules essential for cell division. Not long afterwards, DNA was specified as the essential target, and support for the hypothesis came from evidence that the archetypal agent, mustard gas, could link guanine ...
P D, Lawley, D H, Phillips
openaire +2 more sources
Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999The quantitative relationship between DNA adducts and tumor incidence is evaluated in this review. All available data on DNA adduct levels determined after repeated administration of a carcinogen to rats or mice have been compiled. The list comprised 27 chemicals, of all major structural classes of carcinogens. For the correlation with tumor incidence,
M, Otteneder, W K, Lutz
openaire +2 more sources
DNA Adducts: Endogenous and Induced
Toxicologic Pathology, 2000Human exposure to DNA damaging agents can arise from exogenous sources or endogenous processes that occur normally or in pathological states. DNA isolated from human tissues, obtained from the very young to the old, contains detectable amounts of a number of different types of DNA adducts that reflect exposure to both known carcinogens and as yet ...
openaire +2 more sources