Results 231 to 240 of about 2,409,493 (295)
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2006
DNA adducts reflect the amount of a ▶ xenobiotic that covalently reacts with nucleic acid bases at the target site (biologically effective dose) or in surrogate tissues (▶Surrogate markers). DNA adducts are mechanistically more relevant to ▶ carcinogenesis than the internal dose of a carcinogen, since they take into account interindividual differences ...
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DNA adducts reflect the amount of a ▶ xenobiotic that covalently reacts with nucleic acid bases at the target site (biologically effective dose) or in surrogate tissues (▶Surrogate markers). DNA adducts are mechanistically more relevant to ▶ carcinogenesis than the internal dose of a carcinogen, since they take into account interindividual differences ...
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Journal of Cancer Research and Clinical Oncology, 1986
Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-
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Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-
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Nucleosides and Nucleotides, 1991
Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Pekka Sillanaukee +2 more
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Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Pekka Sillanaukee +2 more
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Studies of chlorambucil—DNA adducts
Biochemical Pharmacology, 1992Chlorambucil (CLB) is a bifunctional nitrogen mustard whose therapeutic and major side-effects are thought to be caused by binding to DNA. HPLC analysis of hydrolyzed DNA from L1210 cells incubated with [14C]CLB generated two peaks of radioactivity, indicating the formation of two or more major adducts.
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DNA adduct assay in cervical epithelium
Diagnostic Cytopathology, 1994AbstractNumerous epidemiological studies have shown that there is an association between smoking and cervical cancer. However, the essential evidence to show whether this relationship is casual or causal is lacking. The demonstration of DNA modification by tobacco components in the cervical epithelium would provide biochemical evidence to support a ...
A M, Simons, D H, Phillips, D V, Coleman
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Specificity of platinum–DNA adduct repair
Journal of Inorganic Biochemistry, 1999Cell lines with resistance to cisplatin and carboplatin often retain sensitivity to platinum complexes with different carrier ligands (e.g., oxaliplatin and JM216). HeLa cell extracts were shown to excise cisplatin, oxaliplatin, and JM216 adducts with equal efficiency, suggesting that nucleotide excision repair does not contribute to the carrier-ligand
S G, Chaney, A, Vaisman
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DNA adducts and human atherosclerotic lesions
International Journal of Hygiene and Environmental Health, 2001It has been hypothesized that mutational events may be involved in the atherogenetic process and that at least a portion of atherosclerotic plaques may be the results of monoclonal proliferation of a single mutated smooth muscle cell (SMC). Therefore, atherosclerosis may be similar to carcinogenesis and may have an environmental etiology.
B, Binková +5 more
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2010
Increased production of reactive oxygen species during oxidative stress can initiate the formation of lipid hydroperoxides, which undergo homolytic decomposition to the α, β-unsaturated aldehydic bifunctional electrophiles, 4-oxo-2(E)-nonenal (ONE), 4-hydroxy-2(E)-nonenal (HNE), 4-hydroperoxy-2(E)-nonenal (HPNE), and malondialdehyde (MDA).
Seon Hwa Lee, Ian A. Blair
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Increased production of reactive oxygen species during oxidative stress can initiate the formation of lipid hydroperoxides, which undergo homolytic decomposition to the α, β-unsaturated aldehydic bifunctional electrophiles, 4-oxo-2(E)-nonenal (ONE), 4-hydroxy-2(E)-nonenal (HNE), 4-hydroperoxy-2(E)-nonenal (HPNE), and malondialdehyde (MDA).
Seon Hwa Lee, Ian A. Blair
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Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
Chemical Reviews, 1999E. Jamieson, S. Lippard
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DNA Adducts and Carcinogenesis
1989A central tenet of cancer research is that tumors arise from cells that have undergone a permanent heritable change in their genetic material. This hypothesis originated from the observation that tumor cells have lost normal growth-control mechanisms and transmit this characteristic to their progeny. It is supported by the findings that most chemically
Frederick A. Beland, Miriam C. Poirier
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