Results 241 to 250 of about 53,252 (284)
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, EarlyView.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source
Transcription‐coupled repair: tangled up in convoluted repair
The FEBS Journal, EarlyView.In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher +3 more
wiley +1 more source
DNA adducts of halogenated hydrocarbons [PDF]
Journal of Cancer Research and Clinical Oncology, 1986 Although formation of DNA adducts has been postulated for several halomethanes, no chemical identification of such adducts has been performed so far. There is, however, evidence that methyl chloride does not act biologically as a DNA methylating agent. 1,2-Dichloroethane and 1,2-dibromoethane are activated through conjugation with glutathione. There is
R. J. Laib +3 more
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Medical Hypotheses, 2019
DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
Basant K. Puri, Jean A. Monro, C. Ijeh
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DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
Basant K. Puri, Jean A. Monro, C. Ijeh
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Toxicology, 1995
Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
Aage Haugen +2 more
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Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
Aage Haugen +2 more
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, 2006 DNA adducts reflect the amount of a ▶ xenobiotic that covalently reacts with nucleic acid bases at the target site (biologically effective dose) or in surrogate tissues (▶Surrogate markers). DNA adducts are mechanistically more relevant to ▶ carcinogenesis than the internal dose of a carcinogen, since they take into account interindividual differences ...
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Nucleosides and Nucleotides, 1991
Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Juhani Vilpo +2 more
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Abstract In this paper we report that acetaldehyde, the major metabolite of ethanol oxidation, is bound to DNA in dose-dependent manner under conditions comparable to physiological.
Juhani Vilpo +2 more
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Identification of DNA Adducts of Methylglyoxal
Chemical Research in Toxicology, 2005Methylglyoxal (MG) is a sugar degradation product, which is endogenously formed by fragmentation of triose phosphates during glycolysis, ketone body metabolism of acetone, and catabolism of threonine. Food, beverages, and medical products are important exogenous sources with concentrations of up to 100 microM MG.
Matthias Frischmann +3 more
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Toxicology Letters, 1995
The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
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The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
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DNA adducts in bronchial biopsies
International Journal of Cancer, 1991AbstractTo investigate the feasibility of measuring DNA‐carcinogen adducts in the lungs of non‐surgical patients, endobronchial biopsies were obtained from 78 patients undergoing routine diagnostic bronchoscopy. Lung cancer was present in 37 (47%) of the patients.
Wan-Fung Kwan +6 more
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