Results 271 to 280 of about 53,252 (284)
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Detection of DNA adducts by bioluminescence
SPIE Proceedings, 2001Luminescent assay for detection ATP is very sensitive with limitation of 10-17 moles. ATP using styrene oxide as a model carcinogen we currently apply a luminescence technique to detect the very low levels of carcinogen-DNA adducts in vitro and in vivo.
Jian Chen +5 more
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Carcinogen–DNA Adduct Formation and DNA Repair
2005Carcinogen–DNA adducts can form following endogenous or exogenous exposure to reactive chemical species, usually electrophiles, that modify the structure of DNA. The DNA repair system comprises the products of more than 150 genes that form discrete units or an apparatus of one to eight proteins, which can detect DNA damage, effect cell cycle arrest if ...
Ainsley Weston, Miriam C. Poirier
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Analysis of DNA adducts in human samples: Acrolein‐derived exocyclic DNA adducts as an example
Molecular Nutrition & Food Research, 2011AbstractAcrolein is an environmental pollutant that is also derived endogenously through lipid peroxidation and protein degradation. The reaction of acrolein with 2′‐deoxyguanosine produces exocyclic 1,N2‐propano‐2′‐deoxyguanosine (AdG) adducts, mutagenic lesions that play important roles in multistage carcinogenesis processes.
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Specificity of platinum–DNA adduct repair
Journal of Inorganic Biochemistry, 1999Cell lines with resistance to cisplatin and carboplatin often retain sensitivity to platinum complexes with different carrier ligands (e.g., oxaliplatin and JM216). HeLa cell extracts were shown to excise cisplatin, oxaliplatin, and JM216 adducts with equal efficiency, suggesting that nucleotide excision repair does not contribute to the carrier-ligand
Alexandra Vaisman, Stephen G. Chaney
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DNA Adducts in Cancer Chemotherapy
Journal of Medicinal ChemistryDNA adducting drugs, including alkylating agents and platinum-containing drugs, are prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction with DNA, resulting in the formation of DNA addition products known as DNA adducts. While these adducts are well-accepted to induce cancer cell death, understanding of their specific
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Immunologic Quantification of Carcinogen-DNA Adducts
1986Sensitive immunological methods for the detection of carcinogen-DNA adducts have recently been developed. These techniques are particularly useful for screening human populations for exposure to environmental carcinogens. Measurement of the biologically effective dose in humans may be useful in detecting carcinogenic hazards and carrying out risk ...
Ling-Ling Hsieh +2 more
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DNA Adducts and Their Biological Relevance
1984Epidemiologic studies of human carcinogenesis have demonstrated that exposure to certain chemicals significantly increases cancer risks. Additionally, the carcinogenic effects of chemicals have been observed in many animal experiments. As a result of these studies, strong regulations have been imposed worldwide to limit exposure to chemical carcinogens,
F. Oesch, G. Doerjer, M. A. Bedell
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Detection of human DNA–carcinogen adducts
Nature, 1992The role of specific chemicals in the aetiology of human cancer can now be assessed using 32P-postlabelling in combination with corroborative biomonitoring techniques.
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Mutation Research/Environmental Mutagenesis and Related Subjects, 1992
E. Marafante, C. Leuratti
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E. Marafante, C. Leuratti
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Endogenous Production of DNA Adducts
Regulatory Toxicology and Pharmacology, 1996Kurt Randerath +3 more
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