Results 101 to 110 of about 109,094 (294)
Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan +17 more
wiley +1 more source
Barcode DNA Tanaman Leilem (Clerodendrum Minahassae L.) Berdasarkan Gen MatK [PDF]
, 2014 Gen matK merupakan gen pengkode protein maturaseK yang terdapat pada kloroplas tumbuhan. Penelitian ini bertujuan untuk menentukan urutan nukleotida dari barcode DNA tanaman leilem (Clerodendrum minahassae L.) berdasarkan gen matK.
Kalangi, C. (Cindy) +2 more
core +2 more sources
Advanced Science, EarlyView.This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu +7 more
wiley +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
, 2015 Smith, V.S.*^ DNA barcoding debate. Debate chair and session organiser. PEET V Meeting. University of Illinois, Champaign-Urbana. USA. Sept. 21-25, 2004.
openaire +2 more sources
DNA barcoding and eDNA barcoding in diatoms
, 2014 Die lichtmikroskopische Bewertung der Diversität von Diatomeen ist eine erfolgreich praktizierte Methode zur Gewässergüteanalyse, die z.B. auch in der Wasserrahmenrichtlinie der Europäischen Union umgesetzt wird. Die vorliegende Arbeit stellt environmental DNA (eDNA) Barcoding als Alternative zur üblichen Untersuchung von Diatomeengesellschaften mit ...
Zimmermann, Jonas +1 more
openaire +3 more sources
Advanced Science, EarlyView.This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou +17 more
wiley +1 more source
An evaluation of genotyping by sequencing (GBS) to map the Breviaristatum-e (ari-e) locus in cultivated barley [PDF]
, 2014 : We explored the use of genotyping by sequencing (GBS) on a recombinant inbred line population (GPMx) derived from a cross between the two-rowed barley cultivar ‘Golden Promise’ (ari-e.GP/Vrs1) and the six-rowed cultivar ‘Morex’ (Ari-e/vrs1) to map ...
Bayer, Micha +8 more
core +4 more sources
Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis
Advanced Science, EarlyView.This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen +7 more
wiley +1 more source
Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus [PDF]
, 2017 Cis-regulatory modules contain multiple transcription factor (TF)-binding sites and integrate the effects of each TF to control gene expression in specific cellular contexts.
Chen, Yujie +14 more
core +2 more sources