Results 221 to 230 of about 66,386 (283)

The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA

open access: yesCancer Communications, EarlyView.
Abstract Background Blood‐based cell‐free DNA (cfDNA) methylation testing has emerged as a promising approach for multi‐cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional bisulfite‐based methods often encounter sensitivity limitations in detecting early‐stage malignancies or certain cancer types.
Hui‐Yan Luo   +37 more
wiley   +1 more source

A composite universal DNA signature for the tree of life. [PDF]

open access: yesNat Ecol Evol
de Medeiros BAS   +7 more
europepmc   +1 more source

Unlocking Biomolecule Modification with Light‐Promoted Photocatalyst‐Free Approaches: Current Tools, Challenges, and Perspectives

open access: yesChemistryEurope, EarlyView.
This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink   +3 more
wiley   +1 more source

Impact of RNA extraction on respiratory microbiome analysis using third-generation sequencing. [PDF]

open access: yesBMC Genomics
Michel A   +8 more
europepmc   +1 more source

Harnessing Synergies between Combinatorial Microfluidics and Machine Learning for Chemistry, Biology, and Fluidic Design

open access: yesChemistry–Methods, EarlyView.
This review explores the synergy of combinatorial microfluidics and machine learning, highlighting their transformative impact on high‐throughput experimentation, closed‐loop reaction optimization, and autonomous platform development. Key applications in chemical synthesis, biological research, and microfluidic design are discussed, addressing ...
Suyash S. Damir   +3 more
wiley   +1 more source

A systematic review evaluating the performance of eDNA methods relative to conventional methods for biodiversity monitoring

open access: yesEcography, EarlyView.
The rapid adoption of environmental DNA (eDNA) methods has drastically changed biodiversity monitoring efforts. It is often claimed that eDNA methods are more sensitive and efficient than conventional biodiversity monitoring methods, but it is often unclear what metrics support this claim.
Nicholas J. Iacaruso   +4 more
wiley   +1 more source

Host Traits Impact the Outcome of Metagenomic Library Preparation From Dental Calculus Samples Across Diverse Mammals. [PDF]

open access: yesMol Ecol Resour
Moraitou M   +11 more
europepmc   +1 more source

Macro‐ and microclimate interactively shape species diversity of multiple taxa in mountain landscapes

open access: yesEcography, EarlyView.
Macroclimate is a key driver of biodiversity, but habitat conditions can modulate the local microclimate by amplifying or buffering macroclimatic temperatures. The interplay between microclimatic modulation and macroclimatic temperature is crucial for shaping local biodiversity in a warming world, but remains poorly understood across life forms.
Lisa Samira Geres   +11 more
wiley   +1 more source

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