Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
DNA barcoding as a complementary tool for conservation and valorisation of forest resources
ZooKeys, 2013 Since the pre-historic era, humans have been using forests as a food, drugs and handcraft reservoir. Today, the use of botanical raw material to produce pharmaceuticals, herbal remedies, teas, spirits, cosmetics, sweets, dietary supplements, special ...
Angeliki Laiou +4 more
doaj +1 more source
Evaluating the Utility of Single-Locus DNA Barcoding for the Identification of Ribbon Worms (Phylum Nemertea). [PDF]
PLoS ONE, 2016 Whereas many nemerteans (ribbon worms; phylum Nemertea) can be identified from external characters if observed alive, many are still problematic. When it comes to preserved specimens (as in e.g.
Per Sundberg +2 more
doaj +1 more source
Using molecular tools to differentiate closely related blackfly species of the genus Simulium [PDF]
, 2009 Biodiversity data are the foundation for conservation and managemet and taxonomy provides the reference system, skills and tools used to identify organisms.
Day, J. C.
core
A record of the Porbeagle, Lamna nasus, in coastal waters of Buenos Aires (Argentina) confirmed by DNA barcoding [PDF]
, 2015 A record of a juvenile Porbeagle, Lamna nasus, in the coastal waters of Argentina is confirmed by DNA barcoding, since the specimen lacked some external diagnostic features.
Díaz de Astarloa, Juan Martín +2 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Evaluation of DNA barcoding reference databases for marine species in the western and central Pacific Ocean [PDF]
PeerJDNA barcoding is a widely used tool for species identification, with its reliability heavily dependent on reference databases. While the quality of these databases has long been debated, a critical knowledge gap remains in their comprehensive evaluation ...
Yufei Zhou +5 more
doaj +2 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
DNA barcoding deep-water zooplankton from the Gulf of Alaska, North Pacific Ocean
Frontiers in Marine ScienceDNA barcoding is a method of identifying individual organisms using short DNA fragments matched to a database of reference sequences. For metazoan plankton, a high proportion of species that reside in the deep ocean still lack reliable reference ...
Jennifer M. Questel +5 more
doaj +1 more source
Protecting an Ecosystem Service: Approaches to Understanding and Mitigating Threats to Wild Insect Pollinators [PDF]
, 2016 Insect pollination constitutes an ecosystem service of global importance, providing significant economic and aesthetic benefits as well as cultural value to human society, alongside vital ecological processes in terrestrial ecosystems.
Arce, AN +26 more
core +1 more source